Comparing Wegovy and Mounjaro: What You Need to Know

The most fundamental difference lies in how each medicine acts on the body. Wegovy contains semaglutide, a GLP-1 receptor agonist — it mimics the GLP-1 hormone involved in appetite regulation and feelings of fullness. Mounjaro contains tirzepatide, a dual GIP and GLP-1 receptor agonist, meaning it acts on two appetite-related pathways rather than one. Both medicines slow gastric emptying to varying degrees, which many people experience as reduced appetite and less preoccupation with food, sometimes called reduced "food noise."

Dose Strengths

When comparing Wegovy and Mounjaro doses, the two medicines use entirely different scales, so the numbers are not directly comparable.

• Wegovy (semaglutide) is typically started at 0.25 mg once weekly and titrated — under prescriber guidance — through 0.5 mg, 1 mg, and 1.7 mg, up to a maintenance dose of 2.4 mg once weekly.
• Mounjaro (tirzepatide) is typically started at 2.5 mg once weekly and titrated — again under prescriber guidance — through 5 mg, 7.5 mg, 10 mg, and 12.5 mg, up to 15 mg once weekly.

In both cases, titration is individually paced and directed by the prescriber — it is never something to adjust on your own. Both medicines carry a black triangle (▼) designation in the UK, indicating they are subject to additional monitoring; any side effects should be reported to your healthcare professional and to your national reporting scheme (such as the UK's Yellow Card scheme).

Both medicines are supplied as pre-filled injection pens and are administered once weekly, typically into the abdomen, thigh, or upper arm. Neither is insulin.

For a broader look at using these medicines together or understanding each in context, see our guides on Wegovy and Mounjaro used in context and the Mounjaro information hub. If you are weighing up other comparisons, our page on comparing Mounjaro with other options may also be useful.

GLP Trackr is built to support people on both Mounjaro and Wegovy — whichever medicine your prescriber has chosen for you. The most relevant feature here is dose and injection logging: each week you can record your dose strength, the date and time of your injection, and the site you used, giving you a clear, timestamped record of exactly where you are in your treatment schedule. The app also tracks injection-site rotation and suggests your next site, so you always know where to inject without having to remember.

Because titration schedules differ between the two medicines, keeping an accurate log matters — especially when discussing your progress with your prescriber at review appointments. The built-in doctor report feature lets you bring a clear summary of your dose history, weight trend, and any side effects you have logged, making those conversations more productive.

If you have questions about how either medicine may interact with other things you take, or about specific circumstances such as taking other medicines alongside Mounjaro or Mounjaro during pregnancy, always raise these directly with your prescriber or doctor — those decisions are clinical and personal to you.

Any decision about which medicine is right for you, or about your dose, should be made with your prescriber — never on your own. GLP Trackr supports your journey once that decision has been made; it is not a substitute for clinical guidance.

Ready to keep your treatment on track? Download GLP Trackr on the App Store or Google Play — your first 7 days are free.