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What Is the Difference Between GLP-1 and GIP?

GLP-1 and GIP are two distinct gut hormones that both play a role in regulating appetite and blood sugar — and understanding them helps explain why some prescribed weight-management medicines work the way they do. GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) act on overlapping but different receptors in the body; certain medicines target one, while others target both simultaneously. Which approach is right for any individual is a decision for their prescriber or doctor, not something to self-determine.

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What Is the Difference Between GLP-1 and GIP?

How GLP-1 and GIP Differ — and Why It Matters

Both GLP-1 and GIP belong to a class called incretins — hormones released by the gut after eating that signal to the body to release insulin and, in the case of GLP-1, to reduce glucagon. They are produced in different parts of the gut and act on receptors found in the brain, pancreas, and other tissues.

GLP-1 (glucagon-like peptide-1)

GLP-1 is released mainly from cells in the lower small intestine and colon. Its actions commonly associated with weight management include reducing appetite, slowing gastric emptying (the rate at which the stomach empties into the small intestine), and increasing feelings of fullness. Semaglutide — the active substance in Wegovy — is a GLP-1 receptor agonist, meaning it mimics and amplifies the effects of the body's own GLP-1.

GIP (glucose-dependent insulinotropic polypeptide)

GIP is released mainly from cells in the upper small intestine (duodenum). It also stimulates insulin release, but its role in appetite regulation is thought to work through different pathways. Research into GIP receptor activation and its contribution to weight management is still evolving; what is clear is that targeting GIP receptors alongside GLP-1 receptors produces effects that differ from targeting GLP-1 alone.

Medicines that target one — or both

This distinction is central to understanding how Mounjaro and Wegovy differ from one another. Wegovy (semaglutide) acts on GLP-1 receptors only. Mounjaro (tirzepatide) is a dual GIP and GLP-1 receptor agonist — it activates both receptor types at the same time. Both medicines are prescription-only and both work differently in different people; only a prescriber can assess which, if either, is appropriate for someone.

It is also worth noting that the term "GLP-1 medicine" is sometimes used loosely to describe this whole class of injectable weight-management treatments. For a closer look at how the terminology is used, see the difference between "GLP" and "GLP-1" as shorthand terms. And if you are already on Mounjaro and want to understand the dose progression, the difference between the 2.5 mg and 5 mg Mounjaro doses is covered separately.

1–2%

average weekly weight change in the first 16 weeks of Mounjaro & Wegovy use*

Tracking the right four numbers — weight, waist, protein and dose — turns a noisy chart into a clear story. That's the loop GLP-1 users keep coming back for.

AI Meal Tracking. Built for GLP 1 Appetites.

Point your camera at any meal and let our AI do the rest. Breakfast, doses, weight, mood all tracked in seconds.

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Whichever Medicine You're On, GLP Trackr Tracks It

GLP Trackr is built for people already prescribed either a GLP-1 medicine or a dual GIP and GLP-1 medicine — whether that is Wegovy, Mounjaro, or another prescribed treatment. The app does not distinguish between them in terms of support: every core feature works regardless of which medicine you take.

The most relevant feature for understanding your own response is the insights and analytics section, which surfaces patterns from your own logged data — weight trends, energy, side effects, and more — so you can build a clearer picture of how your treatment is going over time. Alongside that, the side-effect tracker lets you log symptoms as they occur and view them as a timeline, which can be genuinely useful to bring to a prescriber appointment. You can also log every dose and injection date so nothing gets missed.

For a broader comparison of the two most commonly prescribed medicines in this class, the Wegovy vs Mounjaro overview covers the factual differences in one place.

Any questions about which medicine is right for you, or how your current treatment is working, belong with your prescriber or doctor — they have the full clinical picture that no app can replicate. GLP Trackr helps you record and understand your journey; it is not a substitute for professional medical guidance.

Ready to start tracking? GLP Trackr is available free on the App Store and Google Play, with a 7-day free trial — no commitment needed to see how it fits your routine.

What does glptrackr include?

10+ powerful features. One app. Built specifically for Mounjaro and Wegovy users.

Everything your GLP-1 journey needs. Free to try for 7 days.

Morning Check-In
DAILY

Morning Check-In

Start every day with a 60-second wellness check-in. Log how you're feeling, track nausea, appetite, energy, and mood — giving you and your care team a complete picture of how your medication is working.

Injection Tracking
MEDICATION

Injection Tracking

Log every dose with a single tap. Track your dose history, phase in your cycle, estimated medication levels, and upcoming injection dates — with reminders so you never miss a scheduled shot.

Hydration Reminders
WELLNESS

Hydration Reminders

Staying hydrated is especially important on GLP-1 medications. Set daily water targets, log intake throughout the day, and receive smart nudges when you're falling behind your goal.

Smart Meal Planning
NUTRITION

Smart Meal Planning

Personalized meal plans built around your current dose phase and side effects. Every meal is GLP-1 optimized — high in protein, gentle on the stomach, and scaled to your reduced appetite.

Recipe Library
RECIPES

Recipe Library

Browse 50+ high-protein, GLP-1-friendly recipes filtered by meal type, prep time, and dietary needs. Every recipe includes full nutrition info, step-by-step instructions, and tips for eating with side effects.

Progress Analytics
ANALYTICS

Progress Analytics

Beautiful, easy-to-read charts show your weight loss trajectory, weekly nutrition trends, medication responses, and wellbeing scores over time — turning raw data into genuine insights.

AI Meal Scanning
AI

AI Meal Scanning

Snap a photo of any meal and get a full nutrition breakdown in seconds — calories, protein, carbs, fat, and fibre. No searching. No manual logging. Just point, snap, and track.

Exercise & Steps
FITNESS

Exercise & Steps

Log walks, workouts, and movement with activity targets that flex with your energy levels. On lower-energy dose days, gentler targets keep you moving without burning out.

Community Support
COMMUNITY

Community Support

Connect with thousands of others navigating the same medication journey. Share milestones, ask questions, find accountability partners, and get support from people who truly understand.

Never Forget a Dose Again.

Log your Mounjaro or Wegovy injection in seconds. Track your pen, your dose level, and your injection site — so you always know exactly where you are in your treatment.

Never Forget a Dose Again

Watch Your Body Transform, Week by Week.

Log your weight, measurements, and how you're feeling after each dose. GLPTrackr turns your data into clear, motivating charts that show you how far you've really come.

Watch Your Body Transform

You're Not on This Journey Alone.

Connect with thousands of real GLP-1 users sharing their wins, side effect tips, and meal ideas. Get the support of people who truly get it — because they're living it too.

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  • Track weight, meals, water, exercise, & sleep
  • Log doses, injection sites, & side effects
  • 60-second daily morning check-in
  • AI meal scanning & barcode scanning
  • Personalised AI meal plans & recipes
  • Golden Dose Finder AI
  • Medication Clock — real-time level tracking
  • Daily Brief and predictive side effects
  • Full insights & weekly transformation cards
  • Unlimited progress photos
  • Doctor PDF export & body measurements
  • Community Access—Connect with GLP-1 users

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The Most Advanced GLP-1 Brain Ever Built.

The first AI built exclusively for GLP-1 weight loss. Every insight, every meal plan, every prediction trained on one thing only: helping you get the most out of your medication.

Knows Your Cycle

Knows Your Cycle

GLPIQ tracks where you are in your injection cycle and adjusts everything around it: lighter meals on nausea days, higher protein when appetite returns, and smarter targets as your medication level shifts.

Predicts Before You Feel It

Predicts Before You Feel It

GLPIQ learns your personal side effect patterns over time. After a few cycles, it starts warning you the morning before a rough day — and adjusts your meal plan automatically.

Finds Your Golden Dose

Finds Your Golden Dose

GLPIQ analyses every dose you've been on: weight loss rate, side effects, food noise, mood, protein adherence and tells you which dose gave you the best results. No other app does this.

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Frequently asked questions.

GLP-1 and GIP are both incretin hormones released after eating. GLP-1 is mainly associated with reducing appetite and slowing digestion; GIP acts through different pathways. Some prescribed medicines target GLP-1 only, while others — such as tirzepatide — target both receptors simultaneously.

Semaglutide (Wegovy) acts on GLP-1 receptors only. Tirzepatide (Mounjaro) is a dual GIP and GLP-1 receptor agonist, activating both. Both are prescription-only medicines; a prescriber decides which is appropriate for an individual.

That is a clinical question only a prescriber can answer for any individual. Both medicine types are prescribed for weight management in appropriate patients. No comparison of superiority should guide a personal treatment decision — always discuss suitability with your prescriber or doctor.

Yes. GLP Trackr supports people prescribed either type of medicine — including Wegovy and Mounjaro. Dose logging, side-effect tracking, weight charts, and insights all work regardless of which prescribed treatment you are on.

Any decision to switch, start, or stop a prescribed medicine must be made with your prescriber or doctor. GLP Trackr can help you log your current journey and prepare a summary to discuss at your next appointment, but it does not provide medical or dosing advice.