How GLP-1 Agonists Work in the Body
GLP-1 is a naturally occurring hormone released in the gut after eating. GLP-1 agonists work by binding to GLP-1 receptors, which influences several appetite-regulating pathways. The result, commonly reported by people taking these medicines, includes a greater sense of fullness, reduced appetite, and slower emptying of the stomach — an effect that often becomes less pronounced over time.
It is worth noting that not all GLP-1 agonists work in exactly the same way. Semaglutide, the active substance in Wegovy, acts on GLP-1 receptors alone. Tirzepatide, the active substance in Mounjaro, acts on both GLP-1 and GIP receptors — making it a dual receptor agonist. You can read more about this distinction on our page covering how GLP-1 receptor agonists work.
These are prescription-only medicines. Suitability, dosing, and any adjustments are decisions made by a prescriber based on an individual's full medical history — not something to determine independently. For a broader look at this medicine class, see our guide to GLP-1 medicines and our overview of GLP-1s explained.
Because these medicines affect appetite and digestion, many people experience gastrointestinal side effects — particularly nausea, constipation, or indigestion — especially in the early weeks or after a dose is adjusted by their prescriber. These are commonly reported and often ease with time, though anyone finding symptoms severe or persistent should contact their healthcare professional promptly.
average weekly weight change in the first 16 weeks of Mounjaro & Wegovy use*
Tracking the right four numbers — weight, waist, protein and dose — turns a noisy chart into a clear story. That's the loop GLP-1 users keep coming back for.
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Tracking Your GLP-1 Journey with GLP Trackr
Understanding how your body responds to a GLP-1 agonist over time is one of the most useful things you can do — and that starts with consistent, detailed tracking. GLP Trackr is built specifically for people already on Mounjaro or Wegovy, bringing together the data points that actually matter on this kind of journey.
The side-effect tracker is one of the most valuable features for people new to a GLP-1 agonist. Logging symptoms — nausea, fatigue, digestive changes — alongside the date and your current dose stage lets you spot patterns over time and brings something concrete to share with your prescriber at your next appointment. The app also includes an insights dashboard that helps surface correlations across your logged data, so you can see how factors like sleep, food intake, and energy levels relate to how you feel day to day.
On top of that, the daily check-in takes under a minute and captures mood, energy, food noise, and sleep — a fuller picture of your experience than the scale alone ever gives. You can explore what these look like in practice via our Mounjaro tracking hub.
GLP Trackr helps you record what you experience so you can discuss it meaningfully with your prescriber — it is not a substitute for their guidance, and any concerns about your health or treatment should always go to your healthcare professional first.
Ready to start building a clearer picture of your journey? GLP Trackr is free to try for 7 days — download it on the App Store or Google Play and see what consistent tracking looks like.
What does glptrackr include?
10+ powerful features. One app. Built specifically for Mounjaro and Wegovy users.
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Morning Check-In
Start every day with a 60-second wellness check-in. Log how you're feeling, track nausea, appetite, energy, and mood — giving you and your care team a complete picture of how your medication is working.
Injection Tracking
Log every dose with a single tap. Track your dose history, phase in your cycle, estimated medication levels, and upcoming injection dates — with reminders so you never miss a scheduled shot.
Hydration Reminders
Staying hydrated is especially important on GLP-1 medications. Set daily water targets, log intake throughout the day, and receive smart nudges when you're falling behind your goal.
Smart Meal Planning
Personalized meal plans built around your current dose phase and side effects. Every meal is GLP-1 optimized — high in protein, gentle on the stomach, and scaled to your reduced appetite.
Recipe Library
Browse 50+ high-protein, GLP-1-friendly recipes filtered by meal type, prep time, and dietary needs. Every recipe includes full nutrition info, step-by-step instructions, and tips for eating with side effects.
Progress Analytics
Beautiful, easy-to-read charts show your weight loss trajectory, weekly nutrition trends, medication responses, and wellbeing scores over time — turning raw data into genuine insights.
AI Meal Scanning
Snap a photo of any meal and get a full nutrition breakdown in seconds — calories, protein, carbs, fat, and fibre. No searching. No manual logging. Just point, snap, and track.
Exercise & Steps
Log walks, workouts, and movement with activity targets that flex with your energy levels. On lower-energy dose days, gentler targets keep you moving without burning out.
Community Support
Connect with thousands of others navigating the same medication journey. Share milestones, ask questions, find accountability partners, and get support from people who truly understand.
Never Forget a Dose Again.
Log your Mounjaro or Wegovy injection in seconds. Track your pen, your dose level, and your injection site — so you always know exactly where you are in your treatment.
Watch Your Body Transform, Week by Week.
Log your weight, measurements, and how you're feeling after each dose. GLPTrackr turns your data into clear, motivating charts that show you how far you've really come.
You're Not on This Journey Alone.
Connect with thousands of real GLP-1 users sharing their wins, side effect tips, and meal ideas. Get the support of people who truly get it — because they're living it too.
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Frequently asked questions.
GLP-1 agonists are prescription medicines that mimic the hormone glucagon-like peptide-1, which helps regulate appetite and digestion. Medicines such as semaglutide (Wegovy) and tirzepatide (Mounjaro) belong to this class and are prescribed under medical supervision for weight management.
They bind to GLP-1 receptors in the body, which is commonly associated with increased feelings of fullness, reduced appetite, and slower stomach emptying. Individual responses vary, and these effects are generally most noticeable in the earlier stages of treatment.
Wegovy (semaglutide) is a GLP-1 receptor agonist. Mounjaro (tirzepatide) is a dual GIP and GLP-1 receptor agonist, meaning it acts on an additional receptor pathway. Both are prescription-only medicines; suitability is determined by a prescriber.
Nausea, constipation, diarrhoea, indigestion, and fatigue are among the most commonly reported side effects. They often ease over time, particularly after the initial weeks. Anyone experiencing severe or persistent symptoms should contact their healthcare professional promptly.
GLP Trackr is a tracking app for people already prescribed a GLP-1 medicine. It helps you log side effects, daily wellbeing, and progress so you can spot patterns and have more informed conversations with your prescriber. It does not provide medical advice.