How GLP-1 Drugs Work and What People Commonly Experience
GLP-1 stands for glucagon-like peptide-1, a hormone that plays a role in regulating appetite and blood sugar. Medicines that act on GLP-1 receptors mimic this hormone, which commonly leads to a reduced sense of hunger, increased feelings of fullness, and slower stomach emptying. For many people, this is experienced as a noticeable quietening of "food noise" — the persistent background preoccupation with eating.
Wegovy contains semaglutide, a GLP-1 receptor agonist. Mounjaro contains tirzepatide, which acts on both GLP-1 and GIP receptors — making it a dual agonist. Both are given as once-weekly injections using pre-filled pens, and both are prescription-only medicines. You can read more about what GLP-1 medicines are and explore Mounjaro as a medication in more detail.
Commonly reported side effects
Side effects associated with GLP-1 drugs are well documented and most commonly affect the digestive system. These include nausea, vomiting, diarrhoea, constipation, indigestion, and reflux. Fatigue, headache, dizziness, and reactions at the injection site are also reported by some people. According to NHS guidance, these effects are often most noticeable after a dose increase and tend to ease over time for many people.
Side effects vary considerably from person to person — what one individual experiences may be quite different from another. If any symptom feels severe, persistent, or worrying, contact your healthcare professional promptly. Any side effects you notice should be reported to your prescriber and to your national reporting scheme (such as the UK's Yellow Card scheme).
For a broader overview of the GLP-1 drug class, see our guide to GLP-1 medicines and how they are used.
average weekly weight change in the first 16 weeks of Mounjaro & Wegovy use*
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Tracking Your GLP-1 Drug Journey with GLP Trackr
One of the most useful things you can do while taking a GLP-1 drug is keep a consistent record of how you feel — particularly in the early weeks and after dose changes. GLP Trackr's side-effect tracker lets you log symptoms like nausea, fatigue, or digestive discomfort as they happen, and over time reveals patterns you might not notice day to day. That log can be genuinely useful to bring to your next prescriber appointment.
Alongside side-effect tracking, the app's daily check-in captures your mood, energy, sleep, and a sense of how strong or quiet your appetite feels — the kind of detail that gets lost if you rely on memory alone. Weight and body measurements are tracked with visual charts so you can see your progress as a trend rather than reacting to individual daily readings.
GLP Trackr is built specifically for people already on Mounjaro or Wegovy, so every feature is shaped around the realities of GLP-1 life. You can find more on managing your treatment week to week in our Mounjaro hub.
GLP Trackr is a tracking and journaling tool — it is not a substitute for your prescriber's guidance. Always follow the advice of the healthcare professional who knows your full medical history.
Ready to start building a clearer picture of your journey? Download GLP Trackr on the App Store or Google Play and explore it free for 7 days.
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Morning Check-In
Start every day with a 60-second wellness check-in. Log how you're feeling, track nausea, appetite, energy, and mood — giving you and your care team a complete picture of how your medication is working.
Injection Tracking
Log every dose with a single tap. Track your dose history, phase in your cycle, estimated medication levels, and upcoming injection dates — with reminders so you never miss a scheduled shot.
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Staying hydrated is especially important on GLP-1 medications. Set daily water targets, log intake throughout the day, and receive smart nudges when you're falling behind your goal.
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Frequently asked questions.
A GLP-1 drug is a prescription-only medicine that mimics the GLP-1 hormone to help regulate appetite and blood sugar. Examples include semaglutide (Wegovy) and tirzepatide (Mounjaro). They are taken as once-weekly injections and must be prescribed by a qualified healthcare professional.
The most commonly reported side effects are gastrointestinal — including nausea, vomiting, diarrhoea, constipation, and indigestion. Fatigue, headache, and injection-site reactions are also reported. These effects often ease over time, but if symptoms are severe or persistent, speak with your prescriber or doctor.
For many people, side effects are most noticeable in the days after starting or after a dose increase, and they often ease within a week or two. Experience varies between individuals. Your prescriber is best placed to advise you based on your own history and how you are responding.
No. GLP-1 drugs are not insulin. They work by acting on GLP-1 receptors to influence appetite and digestion rather than directly replacing or supplementing insulin. Your prescriber can explain how the medicine relates to any other treatments you may be taking.
GLP Trackr lets you log side effects, daily energy and mood, weight, and other wellbeing markers over time. The app helps you spot patterns and build a record to discuss with your prescriber. It is available free for 7 days on the App Store and Google Play.