Different Injections, Different Purposes: What the Evidence Says
It is worth being clear about what each type of injection is — and is not — before drawing comparisons with a prescribed GLP-1 medicine.
HCG injections
HCG (human chorionic gonadotropin) has been promoted alongside very-low-calorie diets in some commercial weight-loss programmes. Regulatory bodies in several countries have raised concerns about its safety and lack of demonstrated efficacy for weight loss when used in this way. If you have questions about HCG, speak with your prescriber or doctor rather than acting on online claims.
NAD injections
NAD (nicotinamide adenine dinucleotide) infusions and injections are sometimes marketed for energy and metabolism. The clinical evidence for NAD injections as a weight-loss tool is limited, and their use for this purpose falls outside standard prescribing guidance. Any decision about whether NAD therapy is appropriate for you belongs with your healthcare professional.
Vitamin B injections
Vitamin B12 injections are sometimes linked to weight loss in wellness settings, largely because B12 deficiency can cause fatigue, and correcting it may restore energy levels. There is no robust evidence that B12 injections cause weight loss in people who are not deficient. People on GLP-1 medicines sometimes ask about B12 because metformin — occasionally co-prescribed — can affect B12 absorption; if this is relevant to you, raise it with your prescriber.
Testosterone injections
Testosterone therapy is prescribed for specific hormonal conditions, and some research suggests it can influence body composition in people with clinically low testosterone. It is not a general weight-loss treatment and should only be considered where a prescriber has assessed clinical need.
Methotrexate injections
Methotrexate is an immunosuppressant used for conditions such as rheumatoid arthritis and psoriasis. Weight changes can occur as part of managing these conditions, but methotrexate is not prescribed for weight loss. If you are on both methotrexate and a GLP-1 medicine, your prescriber is the right person to discuss any interactions.
For a broader overview of prescription options in this space, see our guide to weight-loss injections. If you are managing other health conditions alongside your GLP-1 treatment, the page on weight-loss injections and epilepsy shows how people navigate complex health pictures while staying on track.
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How GLP Trackr Supports Your Weekly Injection Routine
Whatever your wider health context, staying consistent with a prescribed weekly GLP-1 injection is one of the most important things you can do — and that is exactly where GLP Trackr helps.
Injection-site tracking and rotation
The app logs each injection by site (abdomen, thigh, or upper arm), date, and dose strength, then suggests your next rotation site automatically. Rotating sites regularly is recommended to avoid build-up of scar tissue and to keep absorption consistent — having a record makes this effortless rather than something you have to remember mentally.
Dose reminders and logging
A once-weekly schedule sounds simple, but real life gets in the way. GLP Trackr sends gentle reminders so you never miss a dose, and every logged shot becomes part of a clear history you can review — or share as a summary with your prescriber at your next appointment.
If you follow a structured eating plan alongside your injection routine, the page on combining Slimming World with weight-loss injections may also be a useful read.
Always follow the guidance of your prescriber or doctor — they know your full medical history and are the right person to advise on any injection, supplement, or combination of treatments. If you experience anything unexpected or worrying, contact your healthcare professional promptly rather than adjusting anything on your own.
Ready to bring your injection routine together in one place? Download GLP Trackr on the App Store or Google Play and start a free 7-day trial — log your sites, set your reminders, and let the app handle the rotation tracking for you.
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Morning Check-In
Start every day with a 60-second wellness check-in. Log how you're feeling, track nausea, appetite, energy, and mood — giving you and your care team a complete picture of how your medication is working.
Injection Tracking
Log every dose with a single tap. Track your dose history, phase in your cycle, estimated medication levels, and upcoming injection dates — with reminders so you never miss a scheduled shot.
Hydration Reminders
Staying hydrated is especially important on GLP-1 medications. Set daily water targets, log intake throughout the day, and receive smart nudges when you're falling behind your goal.
Smart Meal Planning
Personalized meal plans built around your current dose phase and side effects. Every meal is GLP-1 optimized — high in protein, gentle on the stomach, and scaled to your reduced appetite.
Recipe Library
Browse 50+ high-protein, GLP-1-friendly recipes filtered by meal type, prep time, and dietary needs. Every recipe includes full nutrition info, step-by-step instructions, and tips for eating with side effects.
Progress Analytics
Beautiful, easy-to-read charts show your weight loss trajectory, weekly nutrition trends, medication responses, and wellbeing scores over time — turning raw data into genuine insights.
AI Meal Scanning
Snap a photo of any meal and get a full nutrition breakdown in seconds — calories, protein, carbs, fat, and fibre. No searching. No manual logging. Just point, snap, and track.
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Log walks, workouts, and movement with activity targets that flex with your energy levels. On lower-energy dose days, gentler targets keep you moving without burning out.
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GLPIQ learns your personal side effect patterns over time. After a few cycles, it starts warning you the morning before a rough day — and adjusts your meal plan automatically.
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Frequently asked questions.
Regulatory bodies in multiple countries have questioned the safety and efficacy of HCG injections for weight loss. Any very-low-calorie diet associated with HCG protocols carries its own risks. If you are considering HCG, discuss it with your prescriber or doctor before proceeding.
Vitamin B12 injections correct a deficiency and may improve energy levels if you are deficient, but there is no robust evidence they cause weight loss in people with normal B12 levels. If you are concerned about your B12, speak with your healthcare professional.
Mounjaro (tirzepatide) and Wegovy (semaglutide) are prescription-only medicines that act on appetite-regulating pathways. They are distinct from HCG, NAD, or vitamin B injections and are prescribed and supervised by a qualified healthcare professional for approved indications.
GLP Trackr logs each injection by site, date, and dose, suggests your next rotation site automatically, and sends reminders so you never miss a dose. It also builds a history you can discuss with your prescriber. Available free for 7 days on iOS and Android.
Any combination of medicines should be discussed with your prescriber or doctor, who can review your full history and check for potential interactions. GLP Trackr can help you log both injection schedules, but decisions about combining treatments belong with your healthcare professional.