Can Mounjaro or Wegovy Cause Heart Palpitations?
Heart palpitations — the sensation that your heart is beating unusually fast, irregularly, or more forcefully than normal — have been reported by some people taking Mounjaro (tirzepatide) and Wegovy (semaglutide). They appear in the side-effect information for GLP-1 and dual GIP/GLP-1 receptor agonists, though they are not among the most commonly reported effects. According to information on the electronic Medicines Compendium (eMC), heart rate changes are included in the product literature for medicines in this class.
Why might they happen?
GLP-1 receptor agonists, including semaglutide (the active substance in Wegovy), and tirzepatide (the active substance in Mounjaro), can have mild effects on heart rate. The mechanisms are not fully understood in every case, but the GLP-1 pathway does interact with cardiovascular signalling, which may contribute to a modest increase in resting heart rate in some individuals. Dehydration — more likely if you are experiencing nausea, vomiting, or reduced fluid intake — can also contribute to palpitations.
When do they tend to occur?
If palpitations do occur, some people notice them in the first day or two after an injection, or after a dose increase. They often settle as the body adjusts, but this is not universal and should not be assumed. For a closer look at how Mounjaro can affect heart rate specifically, see our page on Mounjaro and heart rate changes. For a deeper dive into palpitations in particular, our page on palpitations during Mounjaro treatment covers the topic in more detail.
When should I seek help?
Certain presentations require prompt attention. Contact your healthcare professional without delay if you experience:
- Palpitations that are rapid, irregular, or accompanied by chest pain or tightness
- Dizziness, fainting, or shortness of breath alongside the palpitations
- Palpitations that are frequent, prolonged, or getting worse rather than better
- Any symptom that feels alarming or unusual for you
These experiences may or may not be related to your medication, but only a healthcare professional can assess them properly. Do not rely on information from an app or website in place of clinical evaluation.
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Tracking Heart-Related Symptoms in GLP Trackr
One of the most practical things you can do when you notice an unusual symptom like palpitations is to record it clearly — when it happened, how long it lasted, how it felt, and what else was going on (your dose day, hydration, sleep, activity level). That kind of detail can be genuinely useful when you speak to your prescriber or doctor.
GLP Trackr's side-effect tracker is built for exactly this. Each time you notice a symptom, you can log it alongside your dose and injection record so the timeline is clear. Over days and weeks, patterns can emerge — for example, whether palpitations tend to cluster in the day or two after your weekly shot, or whether they seem linked to lower water intake. The app also lets you generate a summary of your tracked data to bring to a prescriber appointment, so you're not relying on memory alone.
Beyond side-effect logging, GLP Trackr's daily check-in captures mood, energy, sleep, and water intake — context that can help you and your prescriber understand what was happening on days when symptoms appeared. If you are on Wegovy and curious about the broader relationship between GLP-1 medicines and heart health, our page on Wegovy and cardiovascular health provides balanced, factual background.
For a full overview of what to expect on Mounjaro, including how to track your journey week by week, visit our Mounjaro companion guide.
Important: GLP Trackr is a tracking and journaling tool — it is not a substitute for medical advice. If you are concerned about palpitations or any cardiac symptom, contact your healthcare professional promptly. Any change to your medication should be decided with your prescriber, never on your own. If you experience a side effect you think may be related to your medication, report it through your national reporting scheme (such as the UK's Yellow Card scheme) as directed by your healthcare professional.
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Frequently asked questions.
Heart palpitations have been reported by some people taking Mounjaro (tirzepatide). They are listed in the product literature for medicines of this class. If you experience palpitations, log them and discuss them with your prescriber or doctor, especially if they are frequent, severe, or accompanied by other symptoms.
Both Wegovy (semaglutide) and Mounjaro (tirzepatide) act on GLP-1 pathways and can affect heart rate in some people. Palpitations have been reported with both medicines. Any cardiac symptom should be discussed with your prescriber or doctor regardless of which medicine you are taking.
Seek prompt medical attention if palpitations are rapid, irregular, or come with chest pain, dizziness, fainting, or breathlessness. Contact your healthcare professional without delay in those cases. For mild, brief, and infrequent palpitations, still log them and mention them at your next appointment.
Some people find that palpitations ease as their body adjusts, particularly after a dose increase. However, this varies between individuals and cannot be assumed. Always inform your prescriber or doctor if you are experiencing palpitations so they can assess whether any action is needed.
GLP Trackr lets you log side effects — including palpitations — alongside your dose record and daily check-in data. Tracking the timing, frequency, and context helps you build a clear picture to share with your prescriber at your next appointment.