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How to Inject Wegovy: Injection Sites, Rotation and What to Expect

Wegovy (semaglutide) is given as a once-weekly subcutaneous injection, and the three most commonly used sites are the abdomen, the front of the thigh, and the upper arm. Rotating between these areas each week is important for skin health and comfortable injections — and most people find a simple routine makes the process straightforward very quickly. Your prescriber or doctor will have shown you the technique at the point of prescribing; this page covers the general principles of sites and rotation to support the journey you are already on.

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How to Inject Wegovy: Injection Sites, Rotation and What to Expect

Where to Inject Wegovy: Sites, Rotation and General Guidance

Wegovy is injected into the fatty tissue just beneath the skin — a subcutaneous injection. The three sites most commonly used are:

  • Abdomen — the area around the stomach, avoiding the 5 cm (2 inches) directly around the navel. Many people find this the most accessible spot.
  • Front of the thigh — the outer, fleshy part of the upper leg. A practical choice when injecting at home.
  • Upper arm — the back or outer area of the upper arm. More commonly used when someone else can assist, though some people manage it independently.

Why rotation matters

Using the same spot repeatedly can lead to a build-up of scar tissue under the skin, which may affect how the medicine is absorbed. Rotating to a different site each week — and moving to a different area within each site — helps keep the skin in good condition and ensures consistent absorption. Your prescriber or the patient information leaflet that came with your pen will give you specific guidance on this.

Choosing the best spot for you

There is no single "best" site that applies to everyone — comfort, ease of access, and your prescriber's advice are the main factors. Many people find the abdomen the easiest to reach and inject consistently. If you notice persistent redness, lumps, or soreness at any site, mention it to your healthcare professional before injecting there again.

For a step-by-step visual walkthrough of the injection process, the Wegovy pen injection video guide covers the process in more detail. If you are also curious how the process compares for another GLP-1 medicine, the guide to injecting Mounjaro explains the similarities and differences. For a broader look at injection site guidance across GLP-1 medicines, that page covers the principles in depth.

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Tracking Your Wegovy Injection Sites with GLP Trackr

Keeping track of which site you used last — and exactly where within that site — is easy to forget across a weekly schedule. GLP Trackr's injection-site tracking feature lets you log each injection (site, side, and date) so the app can suggest your next rotation automatically. You never have to rely on memory to work out whether you last used your left thigh or your abdomen.

Alongside site rotation, the app logs your dose strength and the date and time of each injection, giving you a clear record to refer back to — useful if you ever need to check your schedule or bring a summary to a prescriber appointment. Dose reminders mean your weekly injection is less likely to slip past unnoticed on a busy day.

For a wider view of your progress, the weight loss injections hub brings together guidance across every part of the GLP-1 journey.

Log your first injection site today — GLP Trackr is available free on the App Store and Google Play, with a 7-day free trial to get started.

The guidance on this page covers general principles only. Always follow the specific instructions given by your prescriber or doctor, and refer to the patient information leaflet supplied with your pen. If you experience any injection-site reactions that are severe, persistent, or concerning, contact your healthcare professional promptly. Any side effects worth noting can also be reported to your national reporting scheme (such as the UK's Yellow Card scheme) — GLP Trackr can help you log them so nothing gets forgotten before your next appointment.

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Frequently asked questions.

Wegovy is injected subcutaneously — into the fatty tissue under the skin — at one of three main sites: the abdomen (avoiding the area directly around the navel), the front of the thigh, or the upper arm. Your prescriber or patient information leaflet will confirm the best approach for you.

Yes. Rotating to a different site each week helps prevent scar tissue build-up and supports consistent medicine absorption. Many people cycle through the abdomen, thigh, and upper arm, also moving to a slightly different spot within each area each time.

There is no single best spot — it depends on comfort and ease of access. Many people find the abdomen the most convenient. Your prescriber can advise on what works best given your individual circumstances, and the patient information leaflet with your pen provides specific guidance.

Wegovy is a once-weekly injection and can generally be taken at any time of day, with or without food. Choosing a consistent day each week helps build a reliable routine. Your prescriber's guidance and the patient information leaflet are the definitive reference for your personal schedule.

GLP Trackr lets you log each injection — recording the site, side of the body, dose strength, date and time. The app tracks your rotation history and can suggest your next site, so you always know where to inject next without relying on memory.