How to Use Your Wegovy Pen: A Practical Guide for Every Injection

Wegovy (semaglutide) is injected once a week using a pre-filled pen. The three commonly used injection areas are the abdomen (at least a few centimetres from the navel), the front of the thigh, and the upper arm. All three are suitable, and your prescriber or pharmacist can guide you on which works best for your individual circumstances.

Why rotation matters

Injecting into the same spot repeatedly can cause skin changes such as lipohypertrophy — lumpy or hardened tissue that can affect how the medicine is absorbed. Rotating your site at each injection, and varying the exact spot within an area, helps keep the skin healthy. Many people settle into a simple pattern — for example, alternating sides of the abdomen, or moving between the abdomen, thigh, and arm on a rolling basis.

Handling your pen

Before each injection, check the liquid in the pen window — it should appear clear and colourless to slightly yellow, with no particles. The pen should come to room temperature before use (check the leaflet that came with your pen, but typically around 30 minutes out of the fridge is suggested). Never shake the pen. After the injection, hold the pen in place briefly before removing it, as directed in your Patient Information Leaflet (PIL). Always dispose of used pens safely in a sharps bin as advised by your healthcare team.

For full step-by-step technique — including how to prepare the pen, remove the cap, and confirm the dose has been delivered — your PIL and your prescriber or pharmacist are the definitive sources. This page covers general orientation, not clinical injection instruction.

If you use Mounjaro (tirzepatide) rather than Wegovy, the pen device differs — see our guides on how to use the Mounjaro injection and how to use the Mounjaro pen for that medicine's specifics. For a broader look at injectable weight-loss medicines, our weight-loss injections overview covers the wider context.

Keeping track of where and when you last injected is one of those small things that is easy to forget across a weekly schedule — especially when sites like the abdomen have multiple possible positions. GLP Trackr's injection-site tracking feature lets you log each injection, recording the site (abdomen, thigh, or arm) and the side, so you always have a clear history at a glance. Based on your log, the app suggests your next rotation site, making the habit automatic rather than something to remember.

Alongside site tracking, the dose-logging and reminder features mean your weekly schedule stays front of mind. Log the dose strength and date of each injection, and set a gentle reminder so a dose is never accidentally missed — something that matters when you are managing a precise once-weekly routine.

Any notes about how you felt after an injection — mild redness at the site, or anything else worth mentioning — can be recorded in the side-effect log, giving you a clear record to bring to your next prescriber appointment rather than trying to recall details from memory. There is also a doctor report feature that pulls your logged data into a tidy summary, useful for those check-in conversations.

If you are also curious about how the Mounjaro pen compares in terms of the injection experience, our page on how to use Mounjaro walks through that medicine's process.

A note on safety: if you experience anything at an injection site that seems unusual — significant swelling, persistent pain, or signs of infection — contact your healthcare professional promptly. GLP Trackr helps you record what you observe, but it is not a substitute for clinical advice. Your prescriber or pharmacist is always the right person to consult about your injection technique and any concerns.

Ready to take the guesswork out of rotation? Download GLP Trackr on the App Store or Google Play and start your free 7-day trial — log your first injection today and let the app guide your next site.