Why Mounjaro and Wegovy Doses Cannot Be Directly Compared
Mounjaro (tirzepatide) and Wegovy (semaglutide) belong to the same broader class of injectable weight-management medicines, but they are not interchangeable, and their dose numbers are not designed around a shared scale.
Different mechanisms, different dose ranges
Wegovy is a GLP-1 receptor agonist, meaning it acts on one appetite-regulating pathway. Mounjaro is a dual GIP and GLP-1 receptor agonist, acting on two pathways simultaneously. Because the mechanisms differ, the dose figures themselves — milligrams of tirzepatide versus milligrams of semaglutide — are measuring different molecules at different concentrations. A number like "5mg" on one pen does not translate to the same pharmacological effect as "5mg" on the other.
Where Mounjaro 5mg sits in the titration schedule
According to information in the electronic Medicines Compendium, Mounjaro is typically started at 2.5mg once weekly and increased in a stepwise pattern under prescriber guidance. The 5mg dose is the second step in that schedule — not a maintenance or target dose for everyone, but a stage the prescriber uses to help the body adjust gradually. You can read more about what the Mounjaro 5mg dose involves and how it fits into the broader titration journey.
Where Wegovy doses fit
Wegovy also follows a gradual titration, starting at a lower dose and stepping up over several months. Its dose strengths — commonly referenced as 0.25mg, 0.5mg, 1mg, 1.7mg, and 2.4mg — are on a completely different numeric scale from Mounjaro's. The 0.5mg Wegovy dose is one of its early titration steps, not a stage that maps directly to Mounjaro 5mg.
What this means practically
If you are switching between the two medicines — or curious how they compare — the only person who can assess a suitable starting point on the new medicine is your prescriber. Attempting to self-select a "matching" dose based on the numbers is not recommended, and dose decisions always rest with the clinical professional who knows your history.
average weekly weight change in the first 16 weeks of Mounjaro & Wegovy use*
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Wherever you are in your titration — on Mounjaro 5mg, on a Wegovy step, or navigating a transition — keeping a clear record of every dose matters. GLP Trackr's dose logging feature lets you record each injection with its date, time, and dose strength, so you always have an accurate picture of your schedule to refer back to and share with your prescriber.
Alongside dose logging, the app's reminder system helps you stay on your weekly schedule — particularly useful during titration, when the timing of each injection is part of the plan your prescriber has set out. You can also use the injection-site tracker to log where each shot was given and let the app suggest your next rotation site automatically, which is relevant whichever medicine you are on.
If you are curious about how Mounjaro's titration steps compare across the schedule, it is worth exploring what the 7.5mg Mounjaro dose stage involves as context for where the 5mg step leads.
Any decision about your dose — including whether to stay at a current step, move to the next, or switch medicines — should be made with your prescriber, who has the full picture of your health and response. GLP Trackr helps you record your journey accurately so those conversations are better informed; it is not a substitute for clinical advice.
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Frequently asked questions.
There is no direct dose equivalent between Mounjaro 5mg (tirzepatide) and any Wegovy (semaglutide) dose. The two medicines act on different pathways and use different dose scales. Your prescriber or doctor is the right person to advise on suitable dosing for either medicine.
Mounjaro 5mg is generally the second step in the tirzepatide titration schedule, following the initial 2.5mg starting dose. Titration is managed by your prescriber and adjusted based on your individual response and tolerability.
Not directly. The milligram figures refer to different molecules — tirzepatide and semaglutide — at different concentrations. A higher number on one medicine does not mean a stronger or equivalent effect compared to a number on the other. Your prescriber can advise on any comparison relevant to your situation.
GLP Trackr lets you log each injection with the date, time, and dose strength, and sends reminders so you stay on your weekly schedule. Your dose history is stored in the app and can be reviewed before prescriber appointments.
Any switch between medicines — including which dose to start on the new one — should be guided entirely by your prescriber or doctor. Do not attempt to select a dose based on what you were taking on the other medicine. Your prescriber will assess the appropriate starting point for your individual history.