How Semaglutide and Tirzepatide Differ: The Key Facts
The most fundamental difference between the two medicines lies in how they interact with the body's appetite-regulating pathways.
Semaglutide (Wegovy)
- Active substance: semaglutide
- Mechanism: a GLP-1 receptor agonist — it acts on the glucagon-like peptide-1 pathway, which is involved in appetite regulation and feelings of fullness
- How taken: once-weekly injection via a pre-filled pen
- Dose strengths commonly referenced: 0.25, 0.5, 1, 1.7, and 2.4 mg — typically started at the lowest strength and adjusted by the prescriber over time
Tirzepatide (Mounjaro)
- Active substance: tirzepatide
- Mechanism: a dual GIP and GLP-1 receptor agonist — it acts on both the glucose-dependent insulinotropic polypeptide (GIP) pathway and the GLP-1 pathway
- How taken: once-weekly injection via a pre-filled KwikPen device
- Dose strengths commonly referenced: 2.5, 5, 7.5, 10, 12.5, and 15 mg — again, started low and adjusted by the prescriber
What they have in common
Both medicines are prescription-only, both are injectable once a week, and both are associated with commonly reported effects such as reduced appetite, increased feelings of fullness, and slower stomach emptying — an effect that often lessens as the body adjusts. Both also carry a black triangle (▼) designation in the UK, meaning any suspected side effects should be reported to your healthcare professional and to your national reporting scheme (such as the UK's Yellow Card scheme).
Neither medicine is suitable for everyone, and suitability is always determined by a prescriber. For a deeper look at how Wegovy specifically compares to other GLP-1 options, the Wegovy vs Mounjaro comparison guide covers the topic in more detail. You may also find it useful to read about Ozempic compared with Mounjaro if you have questions about tirzepatide alongside other semaglutide-based products.
average weekly weight change in the first 16 weeks of Mounjaro & Wegovy use*
Tracking the right four numbers — weight, waist, protein and dose — turns a noisy chart into a clear story. That's the loop GLP-1 users keep coming back for.
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Whichever Medicine You Are On, GLP Trackr Supports Your Journey
GLP Trackr is built for people already taking Mounjaro or Wegovy — and it works equally well for both. The choice of medicine is your prescriber's; the job of staying consistent, informed, and in control of your own data is where the app comes in.
The feature that tends to matter most for anyone comparing these two medicines is side-effect tracking. Both semaglutide and tirzepatide can cause gastrointestinal symptoms — nausea, bloating, changes in digestion — particularly around dose adjustments. GLP Trackr lets you log how you feel after each injection, tag specific symptoms, and view patterns over time. That log becomes genuinely useful context to bring to your next prescriber appointment, rather than trying to recall weeks of experience from memory.
Alongside that, dose logging keeps a clear record of every injection — the date, the strength, and the injection site — so nothing gets lost in a busy week. And if you are curious how your progress looks across weeks and months, the weight and body-tracking charts give you a picture that goes well beyond the number on the scale.
For a look at how semaglutide products compare with each other, the page on Ozempic versus Wegovy offers useful context on the same active substance in different formulations.
If symptoms feel severe, persistent, or worrying at any point — on either medicine — contact your healthcare professional promptly. GLP Trackr helps you record what you are experiencing so you can discuss it clearly; it is not a substitute for clinical advice, and any decisions about your dose or treatment should always be made with your prescriber.
Ready to bring some structure to your weekly routine? Download GLP Trackr on the App Store or Google Play and try it free for 7 days — no commitment, just a clearer view of your own journey.
What does glptrackr include?
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Morning Check-In
Start every day with a 60-second wellness check-in. Log how you're feeling, track nausea, appetite, energy, and mood — giving you and your care team a complete picture of how your medication is working.
Injection Tracking
Log every dose with a single tap. Track your dose history, phase in your cycle, estimated medication levels, and upcoming injection dates — with reminders so you never miss a scheduled shot.
Hydration Reminders
Staying hydrated is especially important on GLP-1 medications. Set daily water targets, log intake throughout the day, and receive smart nudges when you're falling behind your goal.
Smart Meal Planning
Personalized meal plans built around your current dose phase and side effects. Every meal is GLP-1 optimized — high in protein, gentle on the stomach, and scaled to your reduced appetite.
Recipe Library
Browse 50+ high-protein, GLP-1-friendly recipes filtered by meal type, prep time, and dietary needs. Every recipe includes full nutrition info, step-by-step instructions, and tips for eating with side effects.
Progress Analytics
Beautiful, easy-to-read charts show your weight loss trajectory, weekly nutrition trends, medication responses, and wellbeing scores over time — turning raw data into genuine insights.
AI Meal Scanning
Snap a photo of any meal and get a full nutrition breakdown in seconds — calories, protein, carbs, fat, and fibre. No searching. No manual logging. Just point, snap, and track.
Exercise & Steps
Log walks, workouts, and movement with activity targets that flex with your energy levels. On lower-energy dose days, gentler targets keep you moving without burning out.
Community Support
Connect with thousands of others navigating the same medication journey. Share milestones, ask questions, find accountability partners, and get support from people who truly understand.
Never Forget a Dose Again.
Log your Mounjaro or Wegovy injection in seconds. Track your pen, your dose level, and your injection site — so you always know exactly where you are in your treatment.
Watch Your Body Transform, Week by Week.
Log your weight, measurements, and how you're feeling after each dose. GLPTrackr turns your data into clear, motivating charts that show you how far you've really come.
You're Not on This Journey Alone.
Connect with thousands of real GLP-1 users sharing their wins, side effect tips, and meal ideas. Get the support of people who truly get it — because they're living it too.
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GLPIQ tracks where you are in your injection cycle and adjusts everything around it: lighter meals on nausea days, higher protein when appetite returns, and smarter targets as your medication level shifts.
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GLPIQ learns your personal side effect patterns over time. After a few cycles, it starts warning you the morning before a rough day — and adjusts your meal plan automatically.
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Frequently asked questions.
Semaglutide (found in Wegovy) acts on the GLP-1 pathway only, while tirzepatide (Mounjaro) acts on both GLP-1 and GIP pathways. Both are once-weekly prescription-only injections used in weight management. The right choice for any individual depends on their medical history and is decided by their prescriber.
Neither can be described as universally better. Both are prescription medicines and suitability depends on your individual health history, circumstances, and your prescriber's clinical judgement. This is a decision to make with your prescriber or doctor, not one that can be answered in general terms.
Any switch between prescription medicines is a clinical decision that belongs with your prescriber or doctor. They will consider your full medical history, current progress, and any relevant factors before advising you. Do not start, stop, or switch medication without guidance from your healthcare professional.
Yes. GLP Trackr supports people taking either medicine. You can log doses, track injection sites, record side effects, monitor weight, and build a picture of your journey whichever prescription you have been given.
Both medicines are commonly associated with gastrointestinal effects such as nausea, constipation, and changes in digestion, particularly around dose changes. Individual experience varies. If side effects feel severe or persistent, speak with your healthcare professional promptly rather than managing them alone.