Known Side Effects of Wegovy: What the Evidence Shows
Wegovy contains semaglutide, a GLP-1 receptor agonist that works partly by slowing gastric emptying and acting on appetite-regulating pathways in the brain. These same mechanisms are behind most of the commonly reported side effects, particularly the gastrointestinal ones.
Gastrointestinal effects
The most frequently reported side effects of Wegovy are digestive in nature. These include nausea, vomiting, diarrhoea, constipation, indigestion, reflux, and burping. They are especially common at the start of treatment and after moving to a higher dose — for example, some people notice them more prominently at the 0.5 mg stage when first titrating up, and again when reaching the 2.4 mg maintenance dose. For many people, these effects ease considerably once the body has had a few weeks to adjust.
Other commonly reported effects
Beyond the gut, people on Wegovy sometimes report headaches, dizziness, fatigue, and reactions at the injection site such as redness or mild discomfort. These are generally described as mild to moderate and temporary.
Hair loss
Some people notice increased hair shedding — sometimes called telogen effluvium — during or after significant weight loss on Wegovy. This is generally considered a response to rapid body change and nutritional shifts rather than a direct effect of semaglutide itself. It often resolves over time, but if it concerns you, your prescriber or doctor is the right person to discuss it with.
For a broader look at how GLP-1 medicines affect the body, the overview of side effects common to GLP-1 medicines is a useful companion read. You can also compare experiences by looking at commonly reported side effects of Mounjaro, or read about injection-site reactions specifically.
According to NHS guidance, reporting side effects to your national scheme — such as the UK's Yellow Card scheme, or the equivalent in your country — helps regulators monitor medicine safety over time.
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Tracking Wegovy Side Effects with GLP Trackr
One of the most practical things you can do when side effects arise is keep a clear record of what you experienced, when it happened, and how long it lasted. That information becomes genuinely useful at your next prescriber appointment — and it is exactly what GLP Trackr's side-effect tracker is built for.
Each time you notice a symptom — whether it is nausea after an injection, unusual fatigue, or hair shedding weeks into treatment — you can log it directly in the app. Over time, patterns often emerge: perhaps symptoms are consistently worse on the day after your weekly dose, or they correlate with eating too quickly. The app's insights surface these connections from your own data, so you can have a much more informed conversation with your prescriber rather than trying to reconstruct events from memory.
The daily check-in also lets you note mood and energy levels alongside physical symptoms, which gives a fuller picture of how you are feeling week to week — not just the side-effect moments in isolation.
If you are logging side effects to discuss with your healthcare team, the most challenging side effects people report on Wegovy may help you understand what others have experienced, and for broader context on managing side effects across GLP-1 medicines, the GLP-1 side effects hub covers the wider picture.
GLP Trackr is a tracking tool — it does not replace your prescriber's advice, and nothing logged in the app should be used to make decisions about your dose or treatment. If a side effect is severe, persistent, or worrying you, contact your healthcare professional promptly rather than waiting for your next scheduled appointment.
Ready to start building a clearer picture of your Wegovy journey? Download GLP Trackr on the App Store or Google Play — your first seven days are completely free.
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Start every day with a 60-second wellness check-in. Log how you're feeling, track nausea, appetite, energy, and mood — giving you and your care team a complete picture of how your medication is working.
Injection Tracking
Log every dose with a single tap. Track your dose history, phase in your cycle, estimated medication levels, and upcoming injection dates — with reminders so you never miss a scheduled shot.
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Staying hydrated is especially important on GLP-1 medications. Set daily water targets, log intake throughout the day, and receive smart nudges when you're falling behind your goal.
Smart Meal Planning
Personalized meal plans built around your current dose phase and side effects. Every meal is GLP-1 optimized — high in protein, gentle on the stomach, and scaled to your reduced appetite.
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Browse 50+ high-protein, GLP-1-friendly recipes filtered by meal type, prep time, and dietary needs. Every recipe includes full nutrition info, step-by-step instructions, and tips for eating with side effects.
Progress Analytics
Beautiful, easy-to-read charts show your weight loss trajectory, weekly nutrition trends, medication responses, and wellbeing scores over time — turning raw data into genuine insights.
AI Meal Scanning
Snap a photo of any meal and get a full nutrition breakdown in seconds — calories, protein, carbs, fat, and fibre. No searching. No manual logging. Just point, snap, and track.
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Log walks, workouts, and movement with activity targets that flex with your energy levels. On lower-energy dose days, gentler targets keep you moving without burning out.
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Frequently asked questions.
The most commonly reported side effects of Wegovy (semaglutide) are gastrointestinal — including nausea, vomiting, diarrhoea, constipation, and indigestion. Headache, fatigue, dizziness, and injection-site reactions are also frequently reported. Most are mild to moderate and often ease as the body adjusts.
For many people, side effects like nausea are most noticeable in the first week or two after starting or after a dose increase, and often lessen as the body adjusts. Experiences vary, and if symptoms are severe or do not ease, it is worth speaking with your prescriber or doctor.
Some people on Wegovy notice increased hair shedding, often linked to rapid weight loss rather than semaglutide directly — a process sometimes called telogen effluvium. It typically resolves over time. If hair loss is significant or worrying, discuss it with your prescriber or doctor.
Gastrointestinal side effects can be more noticeable after each dose increase, including at the 2.4 mg stage. Many people find they settle within a few weeks. Your prescriber or doctor can advise if side effects feel unmanageable at any dose level.
Logging each symptom — what it was, when it occurred, and how long it lasted — gives you useful information to share with your prescriber. GLP Trackr's side-effect tracker lets you do this after each dose, and the app's insights help surface patterns from your own data over time.