What the Safety Evidence Shows — and What to Watch For
Wegovy is a once-weekly injectable medicine whose active substance, semaglutide, acts on GLP-1 receptors involved in appetite regulation. It is prescription-only in all major markets, meaning a qualified clinician has assessed your individual history before prescribing it — that assessment is the primary safety layer.
Commonly reported side effects
The most frequently reported effects are gastrointestinal: nausea, vomiting, diarrhoea, constipation, and indigestion. These are particularly common in the early weeks or after a dose increase, and many people find they ease as their body adjusts. Other commonly reported effects include fatigue, headache, dizziness, and injection-site reactions.
For a full list of reported effects, the electronic Medicines Compendium (eMC) holds the official product information for Wegovy, which is worth reading alongside the leaflet in your pack.
When to contact a healthcare professional promptly
Some symptoms warrant prompt attention rather than a wait-and-see approach. These include severe or persistent abdominal pain (which can occasionally signal pancreatic or gallbladder issues), a rapid or sustained heart rate, significant mood changes, or any symptoms you find worrying or unusual. Do not try to manage these by adjusting your dose — contact your prescriber or doctor promptly.
Groups that require particular care
Wegovy is not suitable for everyone. People who are pregnant, trying to conceive, or breastfeeding, those with a personal or family history of certain thyroid conditions, and people with a history of pancreatitis should discuss these factors carefully with their prescriber before or during treatment. Suitability is individual — your clinician knows your full history in a way that any general information source cannot.
If you are also taking insulin or other medicines that affect blood sugar, the interaction risk for hypoglycaemia is something your prescriber should be aware of and monitor.
Wegovy carries a black triangle (▼) designation, meaning it is subject to additional monitoring. If you experience a side effect, reporting it to your national pharmacovigilance scheme — such as the UK's Yellow Card scheme, or whichever scheme operates in your country — helps build the broader safety picture for everyone on this medicine. You can also report directly to your prescriber or pharmacist.
For a broader overview of semaglutide-based treatment, the Wegovy information hub covers what to expect across the journey, and you may also find it useful to compare notes with safety considerations for Mounjaro users if you are ever curious about the tirzepatide side of things.
average weekly weight change in the first 16 weeks of Mounjaro & Wegovy use*
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Using GLP Trackr to Stay on Top of How You Feel
One of the most practical things you can do while on Wegovy is keep a clear record of how your body is responding — not to self-diagnose, but so that when you speak to your prescriber or doctor, you have something concrete to share rather than trying to recall weeks of vague symptoms.
GLP Trackr's side-effect tracking lets you log symptoms as they happen — nausea, fatigue, digestive changes, mood, energy — and surface patterns over time. If nausea is worst in the 24 hours after your injection, or fatigue clusters around a particular day of the week, that kind of pattern is genuinely useful information to bring to an appointment. The app can generate a summary of your logged data — a doctor report — that makes those conversations more productive.
Alongside that, the daily check-in captures mood, sleep, energy, and food-noise in about 30 seconds, giving you a layered picture of your wellbeing rather than just a number on a scale. You can also find broader context about what Wegovy is and how it works, and explore the GLP-1 medicines hub for wider tracking guidance.
GLP Trackr is there to support your tracking and help you have better-informed conversations with your prescriber — it is not a substitute for their advice, and any concerns about your safety or side effects should always go to a qualified healthcare professional first.
Ready to start building a clearer picture of your Wegovy journey? Download GLP Trackr on the App Store or Google Play and explore it free for 7 days.
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Start every day with a 60-second wellness check-in. Log how you're feeling, track nausea, appetite, energy, and mood — giving you and your care team a complete picture of how your medication is working.
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Log every dose with a single tap. Track your dose history, phase in your cycle, estimated medication levels, and upcoming injection dates — with reminders so you never miss a scheduled shot.
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Staying hydrated is especially important on GLP-1 medications. Set daily water targets, log intake throughout the day, and receive smart nudges when you're falling behind your goal.
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Beautiful, easy-to-read charts show your weight loss trajectory, weekly nutrition trends, medication responses, and wellbeing scores over time — turning raw data into genuine insights.
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Log walks, workouts, and movement with activity targets that flex with your energy levels. On lower-energy dose days, gentler targets keep you moving without burning out.
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Frequently asked questions.
Wegovy is a prescription-only medicine approved by regulators after clinical review. Whether it is appropriate for any individual depends on their health history and is a decision made by their prescriber or doctor — not a general information source.
Commonly reported concerns include gastrointestinal side effects (nausea, vomiting, diarrhoea), and rarer but more serious possibilities such as pancreatitis or gallbladder issues. Severe or persistent symptoms should be discussed with a healthcare professional promptly.
Wegovy may not be suitable for people who are pregnant, breastfeeding, trying to conceive, or who have certain thyroid or pancreatic conditions. Suitability is always assessed individually by a prescriber — never by general guidance alone.
Log what you experience so you can discuss it with your prescriber or doctor. For severe, persistent, or worrying symptoms, contact a healthcare professional promptly rather than waiting. You can also report side effects to your national pharmacovigilance scheme.
A tracking app like GLP Trackr can help you log symptoms, spot patterns, and prepare for prescriber appointments — but it is not a medical tool and does not replace clinical advice. Any safety concerns should always go to your prescriber or doctor first.