How the Side-Effect Profiles Compare: Similarities and Differences
Wegovy is a GLP-1 receptor agonist (active substance: semaglutide), while Mounjaro is a dual GIP and GLP-1 receptor agonist (active substance: tirzepatide). Because both act on GLP-1 pathways, their commonly reported side effects overlap significantly.
Shared commonly reported side effects
- Nausea — the most frequently reported symptom with both medicines, particularly after a dose increase
- Vomiting and diarrhoea
- Constipation
- Indigestion, reflux, and burping
- Injection-site reactions (redness, itching, or bruising at the injection point)
- Fatigue and headache, especially early in treatment
These effects are commonly linked to GLP-1 activity — slower gastric emptying in particular — and many people find they ease as the body adjusts, especially after the initial weeks at a new dose.
Where experiences may differ
Because Mounjaro also activates GIP receptors, some people report a subtly different tolerability pattern compared with Wegovy, though head-to-head clinical comparisons are limited and individual responses vary widely. Neither medicine is uniformly better tolerated than the other — what matters most is how your body responds, which your prescriber monitors over time.
Both medicines carry a black triangle (▼) designation in the UK, meaning any suspected side effects should be reported to your national reporting scheme (such as the UK Yellow Card scheme) as well as to your healthcare professional.
For a broader look at how these two medicines differ beyond side effects, see our Wegovy vs Mounjaro overview. If you are also researching semaglutide more widely, our page on Ozempic vs Mounjaro covers the comparison with the lower-dose semaglutide formulation.
According to the electronic Medicines Compendium (eMC), full side-effect information for both medicines is available in their respective Summaries of Product Characteristics — worth reading alongside any conversation with your prescriber.
average weekly weight change in the first 16 weeks of Mounjaro & Wegovy use*
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Tracking Side Effects Whichever Medicine You Are On
One of the most practical things you can do when experiencing side effects on either Mounjaro or Wegovy is to log them consistently — noting when they happen, how severe they feel, and whether they follow a pattern (for example, always appearing in the day or two after your weekly injection).
GLP Trackr's side-effect tracker is built exactly for this. You can log symptoms like nausea, fatigue, or digestive discomfort each day, and over time the app surfaces patterns in your own data — helping you arrive at your next prescriber appointment with a clear, timestamped picture of how you have been feeling rather than relying on memory. The doctor report feature lets you pull that information together neatly before a consultation.
The app supports users on both Wegovy and Mounjaro, so whichever you have been prescribed, your tracking works the same way. For a deeper look at how side effects specifically compare between the two, our Wegovy vs Mounjaro side effects page goes into more detail.
Important: if any side effect is severe, persistent, or worrying — including anything affecting your heart, pancreas, vision, or mental health — contact your healthcare professional promptly. GLP Trackr is a tracking tool; it is not a substitute for clinical advice, and your prescriber is always the right person to guide decisions about your treatment.
Start logging your side effects today — GLP Trackr is available free on the App Store and Google Play, with a 7-day trial so you can see how it fits your journey.
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Start every day with a 60-second wellness check-in. Log how you're feeling, track nausea, appetite, energy, and mood — giving you and your care team a complete picture of how your medication is working.
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Frequently asked questions.
The side-effect profiles overlap significantly. Both commonly cause nausea, vomiting, diarrhoea, constipation, and injection-site reactions, largely because both act on GLP-1 pathways. Individual experiences vary, and your prescriber or doctor is best placed to discuss what to expect.
There is no universal answer. Mounjaro acts on both GIP and GLP-1 receptors while Wegovy acts on GLP-1 alone, which may affect tolerability differently for different people. How well you tolerate either medicine is something to discuss and monitor with your prescriber.
For many people, side effects like nausea are most noticeable in the days following a dose increase and tend to ease as the body adjusts over several weeks. This varies by individual; always follow your prescriber's guidance rather than adjusting your dose yourself.
Yes. Both Wegovy and Mounjaro carry a black triangle (▼) status, and suspected side effects should be reported to your healthcare professional and to your national reporting scheme — for example, the UK Yellow Card scheme. Check your country's scheme for the correct local process.
Yes. GLP Trackr supports users on both Wegovy and Mounjaro. You can log symptoms daily, spot patterns over time, and generate a summary to share with your prescriber. It is a tracking tool, not a source of medical advice.