How Wegovy and Mounjaro Differ: Active Substances and Mechanisms
The most fundamental difference lies in how each medicine acts on the body's appetite-regulating pathways.
Wegovy (semaglutide)
Wegovy contains semaglutide and works as a GLP-1 receptor agonist. GLP-1 is a naturally occurring hormone involved in regulating appetite and feelings of fullness. By mimicking this hormone, semaglutide acts on appetite-regulating centres and slows gastric emptying — meaning food moves more slowly through the stomach, which many people experience as a prolonged sense of fullness. Dose strengths commonly referenced include 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, and 2.4 mg, typically started low and adjusted by the prescriber over time.
Mounjaro (tirzepatide)
Mounjaro contains tirzepatide and is a dual GIP and GLP-1 receptor agonist — meaning it acts on two receptors rather than one. GIP (glucose-dependent insulinotropic polypeptide) is a second appetite-related hormone pathway. Whether activating both receptors meaningfully changes individual experience varies from person to person; your prescriber is best placed to discuss what the pharmacological difference may or may not mean for you. Dose strengths commonly referenced include 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg, again started low with adjustments guided by the prescriber.
What they share
Both medicines are prescription-only, given by subcutaneous injection once a week, and both are subject to additional monitoring — any side effects should be reported to your healthcare professional and to your national reporting scheme (such as the UK's Yellow Card scheme). Neither is insulin, and neither is suitable for everyone — suitability is always a prescriber decision.
For a broader look at how these two medicines compare across several dimensions, see our Wegovy vs Mounjaro comparison guide. You may also find it useful to read about the key differences between Wegovy and Mounjaro or explore what the difference between Wegovy and Mounjaro means in practice.
average weekly weight change in the first 16 weeks of Mounjaro & Wegovy use*
Tracking the right four numbers — weight, waist, protein and dose — turns a noisy chart into a clear story. That's the loop GLP-1 users keep coming back for.
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Whichever You're On, GLP Trackr Tracks It
GLP Trackr is built to support people on both Mounjaro and Wegovy — the app doesn't take sides, and neither should your tracking tool.
The most relevant feature here is the insights and analytics dashboard: as you log your doses, weight, side effects, and daily check-ins over time, GLP Trackr surfaces patterns from your own data — showing how your body is responding week by week, regardless of which medicine you're prescribed. This kind of personal-data picture can be genuinely useful to bring to your prescriber appointments, especially if you want to discuss how things are going or whether your current approach is working.
Alongside insights, the side-effect tracker lets you log anything you notice — nausea, fatigue, changes in appetite — and see how those patterns shift over your treatment. The dose logging and reminder feature means you always know when your last injection was and won't miss your next one, whichever pen you're using.
Any decision about which medicine is right for you, or whether to switch, belongs entirely with your prescriber — GLP Trackr helps you record your journey clearly so those conversations are informed by your real experience, not guesswork.
You can also explore more on what sets these two medicines apart as part of your own research before speaking with your prescriber.
Ready to track your journey properly? Download GLP Trackr on the App Store or Google Play — it's free to start, with a 7-day trial so you can see what it does before committing.
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Morning Check-In
Start every day with a 60-second wellness check-in. Log how you're feeling, track nausea, appetite, energy, and mood — giving you and your care team a complete picture of how your medication is working.
Injection Tracking
Log every dose with a single tap. Track your dose history, phase in your cycle, estimated medication levels, and upcoming injection dates — with reminders so you never miss a scheduled shot.
Hydration Reminders
Staying hydrated is especially important on GLP-1 medications. Set daily water targets, log intake throughout the day, and receive smart nudges when you're falling behind your goal.
Smart Meal Planning
Personalized meal plans built around your current dose phase and side effects. Every meal is GLP-1 optimized — high in protein, gentle on the stomach, and scaled to your reduced appetite.
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Browse 50+ high-protein, GLP-1-friendly recipes filtered by meal type, prep time, and dietary needs. Every recipe includes full nutrition info, step-by-step instructions, and tips for eating with side effects.
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Beautiful, easy-to-read charts show your weight loss trajectory, weekly nutrition trends, medication responses, and wellbeing scores over time — turning raw data into genuine insights.
AI Meal Scanning
Snap a photo of any meal and get a full nutrition breakdown in seconds — calories, protein, carbs, fat, and fibre. No searching. No manual logging. Just point, snap, and track.
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Log walks, workouts, and movement with activity targets that flex with your energy levels. On lower-energy dose days, gentler targets keep you moving without burning out.
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Frequently asked questions.
Wegovy contains semaglutide, a GLP-1 receptor agonist. Mounjaro contains tirzepatide, a dual GIP and GLP-1 receptor agonist that acts on two hormone pathways. Both are prescription-only, once-weekly injectables used in weight management.
That is a decision for your prescriber or doctor, based on your individual health history and circumstances. Neither medicine is universally superior; suitability and response vary between people. GLP Trackr does not recommend one over the other.
Any decision to switch, start, or stop a prescribed medicine should be made with your prescriber — never on your own. GLP Trackr can help you log your current journey and share a clear summary with your prescriber to support that conversation.
Yes. GLP Trackr supports people on both medicines. You can log doses, injection sites, side effects, weight, and food regardless of which medication you have been prescribed, and the app's insights work across both.
They are both prescription-only, once-weekly injectable medicines used in weight management, and both influence appetite-regulating hormone pathways. The key difference is that Mounjaro (tirzepatide) acts on two receptors (GIP and GLP-1), while Wegovy (semaglutide) acts on one (GLP-1).