Which GLP-1 Is Best for Weight Loss?

Mounjaro contains tirzepatide, which acts on two appetite-regulating pathways: GLP-1 and GIP receptors. Wegovy contains semaglutide, which acts on GLP-1 receptors alone. Both medicines work by increasing the sense of fullness, reducing appetite and food noise, and slowing gastric emptying to varying degrees. Because they act through overlapping but distinct mechanisms, individual responses differ — some people do better on one, some on the other, and that pattern is not predictable in advance.

Clinical trial data for each medicine exists, but comparing results across separate trials is not a reliable way to determine what will work for you. Factors such as your starting weight, other health conditions, other medicines you take, and your lifestyle all influence outcomes. This is precisely why the choice of medicine — and the dose — belongs with your prescriber, not a web search.

Beyond the medicine itself, the habits that support your journey matter enormously. Exercise plays a real role: many people find that a combination of cardio and resistance training helps preserve muscle while losing body fat. Nutrition choices — such as prioritising protein, choosing lower-sugar dairy options, eating plenty of fibre-rich foods, and staying well hydrated — can significantly influence how you feel and how your body responds to the medication. These are areas where consistent tracking pays dividends, giving you real data on what is and is not working for your body.

For practical guidance on what to eat alongside your medication, our pages on the best milk choices for your weight loss journey and choosing bread wisely on a GLP-1 plan offer useful, everyday starting points. For a broader look at the whole weight-loss picture, visit our complete weight loss tracking guide.

Progress on GLP-1 medicines is rarely linear. Weight can fluctuate week to week, energy levels shift, and what feels like a plateau may reflect patterns you have not yet spotted. This is where consistent tracking becomes genuinely powerful — not as a substitute for your prescriber's guidance, but as a way to understand your own body better and have more informed conversations at your appointments.

GLP Trackr's weight and body tracking feature logs your weight over time and presents it as a visual trend, so a temporary stall looks very different from a genuine plateau when you can see several weeks of data at once. The insights tools go further — the correlation explorer, for example, can surface connections between your sleep quality, protein intake, hydration, and the direction of your weight trend, helping you identify what levers actually move your results.

If you are trying to find the best app to support your weight loss journey, GLP Trackr is built specifically for people on Mounjaro and Wegovy — it tracks doses, food, weight, mood, and side effects in one place, rather than making you stitch together several different tools.

The daily morning check-in takes under a minute and captures weight, energy, food noise, sleep, and mood — building a rich picture over time that you can share with your prescriber as a summary report.

GLP Trackr supports both Mounjaro and Wegovy users equally. Whatever you have been prescribed, your progress deserves to be tracked properly. Any questions about whether your current medicine or dose is working well for you should always go to your prescriber or doctor — they know your full history and are best placed to advise.

See your weight trend come to life week by week. Download GLP Trackr on the App Store or Google Play and explore it free for 7 days.