What Is the Lowest Dose of Mounjaro and Wegovy?

Both Mounjaro (tirzepatide) and Wegovy (semaglutide) are prescription-only, once-weekly injectable medicines. They are introduced at a low dose to reduce the likelihood and severity of side effects — particularly gastrointestinal ones such as nausea — while your body adapts to the medicine.

Mounjaro lowest dose: 2.5 mg

Mounjaro is available in dose strengths of 2.5, 5, 7.5, 10, 12.5, and 15 mg. The 2.5 mg strength is the starting point. According to the prescribing information held in the electronic Medicines Compendium, this dose is not used for its weight-management effect on its own — it is a tolerability step. How long someone stays at 2.5 mg, and when any increase happens, is decided entirely by their prescriber. If you are just beginning treatment, our guide to what to expect from your first dose of Mounjaro covers what many people notice in those early days.

Wegovy lowest dose: 0.25 mg

Wegovy (semaglutide) follows a similar stepped approach. The lowest dose is 0.25 mg per week, with dose strengths of 0.25, 0.5, 1, 1.7, and 2.4 mg available. The 0.25 mg dose is a tolerability step rather than a therapeutic target. Your prescriber will guide any progression. For a fuller look at Wegovy dosing across the schedule, see our overview of how Wegovy doses are structured.

Why the lowest dose matters

Starting low is a deliberate, evidence-based approach. GLP-1 and GIP receptor agonists affect appetite-regulating pathways and slow gastric emptying, and beginning at the lowest strength gives the digestive system time to adapt. Many people report that side effects are milder at the starting dose than at higher strengths — though experiences vary, and nothing here should be taken as a prediction of your own response.

Any question about whether your starting dose is right for you, or whether it should be adjusted, belongs with your prescriber or doctor. They have your full medical history and are the only person who should guide dose changes.

Staying on top of a weekly injection schedule — especially in the early titration weeks when doses may change — is easier when every shot is recorded in one place. GLP Trackr's dose logging feature lets you record each injection: the dose strength, date, and time, so your history is always clear.

This is particularly useful at the starting dose stage, when you are building a new weekly habit and may want to track how you feel as your body adjusts. The app's side-effect tracking lets you log symptoms like nausea or fatigue alongside each dose entry, building a picture of your experience over time. That record can be genuinely useful to bring to your next prescriber appointment — especially if you want to discuss whether you are ready for a dose increase or need more time at your current strength.

GLP Trackr also includes dose reminders, so a weekly injection is never accidentally missed — something that matters more at the lowest doses, when consistency helps set the foundation for the rest of your journey. You can also explore our page on what changes around the fifth dose of Mounjaro for a sense of how the early weeks tend to evolve for many people, or read about moving to the 5 mg Mounjaro stage for context on what comes after the starting phase.

GLP Trackr helps you record what is happening so you can have better conversations with your prescriber — it is not a substitute for their clinical guidance. If anything about your dose, side effects, or response feels concerning, contact your healthcare professional promptly.

Download GLP Trackr on the App Store or Google Play and start a free 7-day trial — log your dose today and begin building the record that travels with you through every stage of your treatment.