How Mounjaro and Ozempic Differ: The Key Facts
Both medicines are prescription-only, once-weekly injectables, but they work through distinct mechanisms and carry different licensed indications — details that matter when your prescriber is deciding what to recommend.
Active substances and mechanism
- Ozempic contains semaglutide, a GLP-1 receptor agonist. It mimics the GLP-1 hormone, which plays a role in regulating appetite and blood glucose.
- Mounjaro contains tirzepatide, a dual GIP and GLP-1 receptor agonist. It acts on both the GIP and GLP-1 pathways simultaneously.
Licensed indications
Ozempic is licensed primarily for the management of type 2 diabetes in adults. Wegovy — which contains the same active substance, semaglutide, at a higher dose — is the formulation licensed specifically for chronic weight management. Mounjaro holds a licence for both type 2 diabetes management and chronic weight management (at the doses approved for that purpose). Your prescriber will take your full medical history into account when deciding which medicine, if any, is appropriate for you.
Dose strengths
Both medicines are started at a low dose and increased gradually, but the specific strengths differ. Tirzepatide (Mounjaro) is commonly referenced at strengths of 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg. Semaglutide for weight management (Wegovy) is commonly referenced at 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, and 2.4 mg. Any dose adjustment is made by your prescriber — not independently.
Side-effect profiles
Both medicines share a broadly similar range of commonly reported side effects, largely gastrointestinal in nature: nausea, vomiting, diarrhoea, constipation, and indigestion are among those most frequently noted. These are often most noticeable after a dose increase and tend to ease over time for many people. If side effects are severe, persistent, or concerning, contact your healthcare professional promptly. Both medicines carry a black triangle (▼) designation in the UK, meaning they are subject to additional monitoring; side effects should be reported to your national reporting scheme (such as the UK's Yellow Card scheme) and to your healthcare professional.
If you are weighing up the options for weight loss specifically, the page comparing Mounjaro and Ozempic for weight loss looks at this in more detail. You may also find the pages on Mounjaro or Wegovy and which may suit you better useful context, since Wegovy (not Ozempic) is the semaglutide formulation licensed for weight management.
average weekly weight change in the first 16 weeks of Mounjaro & Wegovy use*
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GLP Trackr is built for people already on Mounjaro or Wegovy (semaglutide), and fully supports both medicines. If you have just started your prescription and are finding the weekly injection schedule unfamiliar, the app's dose and injection-site logging is a practical place to begin — every injection is recorded with date, dose strength, and site, and the app suggests where to rotate next so you never have to remember manually.
Side effects are one of the most common reasons people have questions about their medicine, and the side-effect tracker lets you log how you feel after each dose and spot patterns over time. That log becomes genuinely useful to bring to your next prescriber appointment — a clear record rather than a vague recollection.
For a broader view of how these medicines compare in the context of a tracked journey, the Wegovy vs Mounjaro guide is a good starting point.
Whatever your prescription, the decision about which medicine is right for you — and at what dose — belongs with your prescriber or doctor. GLP Trackr helps you track the journey once that decision has been made; it is not a substitute for clinical advice.
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Frequently asked questions.
Mounjaro contains tirzepatide, a dual GIP and GLP-1 receptor agonist, while Ozempic contains semaglutide, a GLP-1 receptor agonist only. They have different licensed indications and dose strengths. Your prescriber or doctor will determine which is appropriate for your situation.
That is a question for your prescriber or doctor, who will consider your full medical history. Ozempic is not licensed specifically for weight management; Wegovy (also semaglutide, at a higher dose) is. Mounjaro holds a weight management licence. Individual responses to both medicines vary considerably.
Any decision to switch, start, or stop a prescribed medicine should be made with your prescriber or doctor — never independently. They will assess whether a change is appropriate based on your health history, current response, and licensed indications.
Yes. GLP Trackr is designed for people already prescribed Mounjaro (tirzepatide) or Wegovy (semaglutide). It supports dose logging, injection-site tracking, side-effect recording, and progress monitoring regardless of which medicine you have been prescribed.
Both contain semaglutide, but they are different products with different licensed indications and dose ranges. Ozempic is primarily licensed for type 2 diabetes management; Wegovy is licensed for chronic weight management. Your prescriber will advise which is relevant to you.