How Mounjaro and Wegovy Differ: The Key Facts
The most fundamental difference is the mechanism of action. Wegovy contains semaglutide, a GLP-1 receptor agonist — it mimics a hormone involved in appetite regulation and slows gastric emptying, which many people experience as reduced hunger and a quieter relationship with food. Mounjaro contains tirzepatide, a dual GIP and GLP-1 receptor agonist, meaning it acts on two appetite-related pathways rather than one.
Active substances at a glance
- Mounjaro: tirzepatide — dual GIP + GLP-1 receptor agonist; once-weekly injection
- Wegovy: semaglutide — GLP-1 receptor agonist; once-weekly injection
Dose ranges
The two medicines use entirely different dose scales, so no straightforward milligram-for-milligram equivalence exists. Mounjaro is typically started at 2.5 mg and titrated — under prescriber direction — through 5, 7.5, 10, 12.5, and up to 15 mg. Wegovy begins at 0.25 mg and steps through 0.5, 1, and 1.7 mg up to a maintenance dose of 2.4 mg. For a closer look at how the titration schedules compare, see our page on Mounjaro and Wegovy dosage differences. Because the numbers sit on completely different scales, comparing doses between the two medicines is not clinically meaningful without prescriber input.
Side-effect profiles
Both medicines share a similar category of commonly reported side effects, largely reflecting their shared GLP-1 action: nausea, vomiting, diarrhoea, constipation, indigestion, and injection-site reactions are reported with both. Because tirzepatide also acts on GIP receptors, the two profiles are not identical, but gastrointestinal effects dominate both lists. Side effects are generally most noticeable after a dose is introduced or increased, and many people find they ease with time. If any side effect is severe, persistent, or worrying, contact your healthcare professional promptly rather than adjusting your dose on your own.
Both medicines carry a black triangle (▼) designation in some markets, meaning they are subject to additional monitoring. Report any suspected side effects to your national reporting scheme (such as the UK's Yellow Card scheme) and discuss them with your healthcare professional. You can find factual information about both medicines via the electronic Medicines Compendium (eMC).
What about Ozempic?
Ozempic also contains semaglutide but is licensed for a different indication — if you are researching how all three relate to one another, our overview comparing Ozempic, Mounjaro, and Wegovy covers the broader picture. For a direct look at semaglutide products side by side, see our page on Ozempic vs Wegovy.
average weekly weight change in the first 16 weeks of Mounjaro & Wegovy use*
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Whichever You're On, GLP Trackr Tracks It
GLP Trackr is built to work alongside both Mounjaro and Wegovy — the app does not favour one medicine over the other, because the choice of medicine is your prescriber's, not ours.
Where the app genuinely helps is in side-effect tracking: you can log symptoms like nausea, fatigue, or digestive discomfort after each dose and review patterns over time. Seeing whether side effects cluster around injection day, or shift as your dose changes, gives you something concrete to bring to your prescriber appointment rather than relying on memory. The app's doctor report feature lets you export a clear summary of your logged journey — doses, side effects, weight trend, and wellbeing check-ins — ready to share at a consultation.
Alongside that, dose and injection logging means every shot is recorded with its date, strength, and site, so you always know where you are in your schedule regardless of which medicine you have been prescribed.
The decision between Mounjaro and Wegovy — or any question about switching, dose equivalence, or suitability — always belongs with your prescriber or doctor. GLP Trackr helps you record your experience clearly so those conversations are better informed, not replace them.
For a broader look at how these medicines compare from a prescribing and clinical perspective, the Wegovy vs Mounjaro information hub brings together the full picture. You may also find our page on manufacturer context for Mounjaro and Wegovy useful background reading.
Ready to start tracking? GLP Trackr is free to try for 7 days — available on the App Store and Google Play. Log your doses, monitor how you feel, and arrive at every prescriber appointment with a complete picture of your journey.
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Start every day with a 60-second wellness check-in. Log how you're feeling, track nausea, appetite, energy, and mood — giving you and your care team a complete picture of how your medication is working.
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Frequently asked questions.
Mounjaro contains tirzepatide, a dual GIP and GLP-1 receptor agonist, while Wegovy contains semaglutide, a GLP-1 receptor agonist only. Both are once-weekly prescription injections used in weight management, but they act on different hormonal pathways.
Both medicines commonly cause gastrointestinal effects such as nausea, vomiting, diarrhoea, and constipation. The profiles are similar due to their shared GLP-1 action, but not identical. If side effects are severe or persistent, contact your healthcare professional promptly.
That comparison is a clinical question for your prescriber or doctor, who will consider your full medical history and circumstances. GLP Trackr does not recommend one medicine over the other; both are prescription-only and suitability is an individual decision.
No direct milligram-for-milligram equivalence exists — the two medicines use completely different dose scales (Mounjaro: 2.5–15 mg; Wegovy: 0.25–2.4 mg). Any question about dose comparison or switching should be discussed with your prescriber.
Yes. GLP Trackr supports people prescribed either medicine. You can log doses, injection sites, side effects, weight, and food regardless of which medicine your prescriber has recommended, and export a summary to share at appointments.