How Wegovy and Mounjaro Differ: The Key Facts
The most important distinction between the two medicines lies in their active substances and how they work in the body.
Wegovy (semaglutide)
Wegovy contains semaglutide and works as a GLP-1 receptor agonist. It acts on the GLP-1 pathway, which is involved in appetite regulation and the feeling of fullness. It is supplied as a pre-filled pen and is injected once a week. Dose strengths commonly referenced include 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, and 2.4 mg, with the starting dose typically low and adjusted over time by the prescriber.
Mounjaro (tirzepatide)
Mounjaro contains tirzepatide and works as a dual GIP and GLP-1 receptor agonist — meaning it acts on two appetite-related pathways rather than one. It is also supplied as a pre-filled pen and injected once a week. Commonly referenced dose strengths include 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg. As with Wegovy, dose adjustments are made by the prescriber, not independently.
Side effects: what is commonly reported
Both medicines share a broadly similar side-effect profile, given their shared GLP-1 mechanism. Commonly reported effects for both include nausea, vomiting, diarrhoea, constipation, indigestion, fatigue, and injection-site reactions. Neither medicine is free of side effects, and individual experience varies considerably. It would not be accurate to state that one medicine definitively causes fewer side effects than the other for all people — this is something to discuss with your prescriber or doctor based on your own health history.
Both medicines carry additional monitoring requirements and are subject to pharmacovigilance reporting. If you experience a suspected side effect, you should report it to your healthcare professional and through your national reporting scheme (such as the UK's Yellow Card scheme).
For a deeper look at how the two medicines compare across multiple dimensions, see our full Wegovy vs Mounjaro comparison guide. You may also find it useful to read about which medicine might be considered best — keeping in mind that the answer is always individual and prescriber-led.
What about other weight management medicines?
Searches for "orlistat or Mounjaro", "Mysimba or Mounjaro", and "Saxenda or Mounjaro" reflect genuine curiosity about the broader landscape of weight management treatments. These are different medicines with different mechanisms, forms, and prescribing criteria. Any comparison between them for your own situation is a conversation to have with your prescriber — they will consider your full medical history, current medicines, and individual circumstances before making any recommendation.
average weekly weight change in the first 16 weeks of Mounjaro & Wegovy use*
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AI Meal Tracking. Built for GLP 1 Appetites.
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Whichever You're On, GLP Trackr Supports Your Journey
GLP Trackr is built for people already taking either Wegovy or Mounjaro — and it works the same way regardless of which medicine you have been prescribed.
Because both medicines involve weekly injections with rotating sites, the most immediately useful feature for many users is injection-site tracking. Each time you inject, you log the site — abdomen, thigh, or upper arm — and GLP Trackr keeps a rotation history so it can suggest where to inject next. Over weeks and months, this takes the guesswork out of rotation entirely.
If you are trying to understand patterns in how you feel — whether that's nausea, fatigue, or changes in appetite — the side-effect and daily check-in logging features let you record symptoms alongside mood, energy, and sleep. That logged history can be genuinely useful to bring to your next prescriber appointment, rather than trying to recall how you felt three weeks ago.
The app also brings together weight tracking, food logging, and insights in one place, so you can see your full journey rather than just the number on the scale.
Explore more on what makes Wegovy and Mounjaro different in practice, or take a look at how Ozempic compares to Mounjaro if that question has come up for you.
A note on safety: any questions about which medicine is right for you, whether to switch, or how to manage side effects should always be directed to your prescriber or doctor — they know your full health picture. GLP Trackr helps you record your experience and stay consistent; it is not a substitute for professional medical guidance.
Ready to start logging your journey? GLP Trackr is free to try for 7 days — available now on the App Store and Google Play, built specifically for life on Mounjaro or Wegovy.
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Morning Check-In
Start every day with a 60-second wellness check-in. Log how you're feeling, track nausea, appetite, energy, and mood — giving you and your care team a complete picture of how your medication is working.
Injection Tracking
Log every dose with a single tap. Track your dose history, phase in your cycle, estimated medication levels, and upcoming injection dates — with reminders so you never miss a scheduled shot.
Hydration Reminders
Staying hydrated is especially important on GLP-1 medications. Set daily water targets, log intake throughout the day, and receive smart nudges when you're falling behind your goal.
Smart Meal Planning
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Browse 50+ high-protein, GLP-1-friendly recipes filtered by meal type, prep time, and dietary needs. Every recipe includes full nutrition info, step-by-step instructions, and tips for eating with side effects.
Progress Analytics
Beautiful, easy-to-read charts show your weight loss trajectory, weekly nutrition trends, medication responses, and wellbeing scores over time — turning raw data into genuine insights.
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Log walks, workouts, and movement with activity targets that flex with your energy levels. On lower-energy dose days, gentler targets keep you moving without burning out.
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Frequently asked questions.
Wegovy contains semaglutide, a GLP-1 receptor agonist. Mounjaro contains tirzepatide, which acts on both GLP-1 and GIP receptors. Both are prescription-only, once-weekly injectables for weight management. The right choice for any individual is decided by their prescriber or doctor.
Neither medicine can be declared universally better for weight loss. Individual response varies depending on health history, other medicines, dose, and lifestyle factors. Your prescriber or doctor is best placed to advise on which treatment suits your specific circumstances.
Both medicines share a broadly similar side-effect profile, including commonly reported nausea, digestive changes, and fatigue. Individual experience differs considerably. It is not accurate to say one definitively causes fewer side effects than the other — discuss your experience with your prescriber or doctor.
Any decision to switch between medicines must be made with your prescriber or doctor, never independently. They will consider your medical history, current dose, and individual response before advising on any change.
Yes. GLP Trackr is built for people already taking either Wegovy (semaglutide) or Mounjaro (tirzepatide). Features including dose logging, injection-site rotation tracking, side-effect logging, and weight tracking work for both medicines.