Wegovy and Mounjaro: How They Differ Factually
Wegovy and Mounjaro share some common ground — both are once-weekly injectable prescription medicines used alongside diet and activity for weight management — but they work through different mechanisms and contain different active substances.
Active substance and mechanism
- Wegovy contains semaglutide, a GLP-1 receptor agonist. It acts on GLP-1 pathways involved in appetite regulation and feelings of fullness.
- Mounjaro contains tirzepatide, a dual GIP and GLP-1 receptor agonist. It acts on both GIP and GLP-1 pathways — a distinction that makes it a different class of medicine from semaglutide-based treatments.
How they are taken
Both medicines are supplied as pre-filled injection pens and are administered once a week. Both are typically started at a low dose and adjusted over time — but any adjustment is made by the prescriber, based on individual response and tolerability, never independently.
Commonly reported side effects
The most commonly reported side effects for both medicines are gastrointestinal in nature — nausea, vomiting, diarrhoea, constipation, and indigestion appear frequently in patient information for each. Injection-site reactions, fatigue, and headache are also commonly noted. Neither medicine is without side effects, and individual experience varies considerably. If you experience anything severe, persistent, or worrying, contact your healthcare professional promptly.
For a broader look at how these medicines compare across more areas, see our Wegovy vs Mounjaro overview, or explore the more detailed discussion in choosing between Wegovy or Mounjaro.
It is also worth noting that neither medicine is insulin, neither is suitable for everyone, and suitability is always determined by a prescriber. Both carry a black triangle (▼) designation in the UK, meaning side effects should be reported to your national reporting scheme (such as the UK's Yellow Card scheme) and to your healthcare professional.
average weekly weight change in the first 16 weeks of Mounjaro & Wegovy use*
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Whichever You Are Prescribed, GLP Trackr Tracks It
GLP Trackr is built to support people on both Mounjaro and Wegovy — the app does not favour one medicine over the other, just as no comparison of these two should.
The most useful place to start, regardless of which medicine you take, is the dose and injection log. Every weekly shot can be recorded with the date, dose strength, and injection site, and the app tracks your rotation history to suggest where to inject next. Over weeks, that log becomes a clear, shareable record of your treatment history — exactly the kind of summary that can be useful to bring to a prescriber appointment.
Beyond injections, the side-effect tracker lets you note how you feel after each dose — nausea, fatigue, digestive changes — and surfaces patterns over time. Whether you are navigating the early weeks on either medicine or adjusting to a new dose stage, having a clear log to discuss with your prescriber is far more useful than trying to recall it from memory.
GLP Trackr also helps you track weight, food, mood, and energy, giving you a complete picture of your journey rather than just a number on the scale.
The question of which medicine is best is genuinely one for your prescriber — they know your health history, your goals, and what is appropriate for you. What GLP Trackr offers is consistency and insight, whichever path you are on. You might also find it helpful to read about what makes one option preferable to the other for different people, or explore how Ozempic compares to Mounjaro if that is relevant to your situation.
Ready to track your journey properly? Download GLP Trackr on the App Store or Google Play and try it free for 7 days — your dose log, side-effect tracker, and progress charts are all waiting.
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Morning Check-In
Start every day with a 60-second wellness check-in. Log how you're feeling, track nausea, appetite, energy, and mood — giving you and your care team a complete picture of how your medication is working.
Injection Tracking
Log every dose with a single tap. Track your dose history, phase in your cycle, estimated medication levels, and upcoming injection dates — with reminders so you never miss a scheduled shot.
Hydration Reminders
Staying hydrated is especially important on GLP-1 medications. Set daily water targets, log intake throughout the day, and receive smart nudges when you're falling behind your goal.
Smart Meal Planning
Personalized meal plans built around your current dose phase and side effects. Every meal is GLP-1 optimized — high in protein, gentle on the stomach, and scaled to your reduced appetite.
Recipe Library
Browse 50+ high-protein, GLP-1-friendly recipes filtered by meal type, prep time, and dietary needs. Every recipe includes full nutrition info, step-by-step instructions, and tips for eating with side effects.
Progress Analytics
Beautiful, easy-to-read charts show your weight loss trajectory, weekly nutrition trends, medication responses, and wellbeing scores over time — turning raw data into genuine insights.
AI Meal Scanning
Snap a photo of any meal and get a full nutrition breakdown in seconds — calories, protein, carbs, fat, and fibre. No searching. No manual logging. Just point, snap, and track.
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Log walks, workouts, and movement with activity targets that flex with your energy levels. On lower-energy dose days, gentler targets keep you moving without burning out.
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Frequently asked questions.
Neither medicine can be called universally better — the right choice depends on an individual's health history, circumstances, and prescriber's judgement. Wegovy contains semaglutide (a GLP-1 agonist); Mounjaro contains tirzepatide (a dual GIP and GLP-1 agonist). Only a prescriber or doctor can determine which is appropriate for you.
Wegovy contains semaglutide, a GLP-1 receptor agonist. Mounjaro contains tirzepatide, a dual GIP and GLP-1 receptor agonist. Both are once-weekly prescription injections for weight management, but they work through different mechanisms and are different medicines entirely.
Any decision to switch between medicines is a clinical one and must be made with your prescriber or doctor — never independently. They will consider your full health history, current response, and individual suitability before making any change to your treatment.
Yes. GLP Trackr supports people on both Mounjaro and Wegovy. You can log doses, track injection sites, record side effects, monitor weight and food, and view progress insights regardless of which medicine you have been prescribed.
Both medicines commonly cause gastrointestinal side effects such as nausea, diarrhoea, and constipation, among others. Individual experience varies and is not identical between medicines. If any side effect is severe, persistent, or concerning, contact your healthcare professional promptly.