Situations Where Mounjaro or Wegovy May Not Be Suitable
The following are among the contraindications and cautions most commonly associated with tirzepatide and semaglutide, drawn from official prescribing information. This is not an exhaustive list, and your prescriber or doctor is the only person who can assess your individual circumstances.
Personal or family history of certain thyroid conditions
Both Mounjaro and Wegovy carry cautions regarding a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Anyone with such a history should discuss this explicitly with their prescriber before starting treatment.
Previous serious allergic reactions to the active substance
A known hypersensitivity to tirzepatide (Mounjaro) or semaglutide (Wegovy) — or to any excipient in the formulation — is a reason these medicines would not be prescribed. Your prescriber or pharmacist can review the full ingredient list with you.
Pregnancy, breastfeeding, or planning to conceive
Neither medicine is recommended during pregnancy or breastfeeding. If you are pregnant, think you may be pregnant, or are planning a pregnancy, speak with your prescriber or doctor promptly. This is a special-care topic: always seek personalised clinical guidance rather than relying on general information.
Pancreatitis history
A personal history of pancreatitis is a significant caution. Your prescriber needs to know about any previous episodes before these medicines are considered. If you experience severe, persistent abdominal pain while taking either medicine, contact a healthcare professional without delay.
Severe gastrointestinal conditions
People with certain serious digestive disorders — such as gastroparesis or severe inflammatory bowel conditions — may not be suitable candidates, since both medicines affect how quickly the stomach empties. Your prescriber or doctor will weigh this up as part of your assessment.
Type 1 diabetes or insulin-dependent diabetes
Mounjaro and Wegovy are not indicated as treatments for type 1 diabetes. For people with type 2 diabetes who also take insulin or sulfonylureas, there are specific considerations around hypoglycaemia risk that your prescriber will need to address — whether Mounjaro is right for you depends on your full diabetes management plan.
Children and young people
These medicines are generally not prescribed to people under 18 unless a prescriber has specifically determined otherwise. Suitability for younger patients is a clinical decision made on an individual basis.
For a broader overview of tirzepatide, visit the Mounjaro information hub. You can also read more about specific groups who should avoid Mounjaro and explore background facts about Mounjaro for additional context. Official prescribing information is published on the electronic Medicines Compendium (eMC), where the full SmPC for each medicine is available.
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Frequently asked questions.
Mounjaro (tirzepatide) is not suitable for people with a personal or family history of medullary thyroid carcinoma, known hypersensitivity to tirzepatide, a history of pancreatitis, or who are pregnant or breastfeeding, among other contraindications. A prescriber assesses your full history before prescribing.
Wegovy (semaglutide) shares many of the same cautions as Mounjaro — including thyroid cancer history, known hypersensitivity, pancreatitis history, and pregnancy or breastfeeding. Suitability is always determined by a prescriber based on your individual medical history.
A personal history of pancreatitis is a significant caution for both Mounjaro and Wegovy. Discuss any previous pancreatitis episodes with your prescriber or doctor before starting either medicine. If you develop severe abdominal pain while taking them, seek medical attention promptly.
Mounjaro is not recommended during pregnancy or breastfeeding. If you are pregnant, planning a pregnancy, or think you may be pregnant, speak with your prescriber or doctor as soon as possible for personalised guidance on your treatment.
No — suitability is a clinical decision for your prescriber or doctor, not something an app can determine. GLP Trackr is a tracking tool for people already prescribed Mounjaro or Wegovy, helping you log doses, symptoms, and progress to support informed conversations with your healthcare team.