Who Shouldn't Take Mounjaro? What You Need to Know

According to product information aligned with the electronic Medicines Compendium (eMC), there are specific groups for whom Mounjaro is contraindicated or requires particular caution. Understanding these helps you have a more informed conversation with your healthcare team.

Absolute contraindications

• Personal or family history of medullary thyroid carcinoma (MTC): Mounjaro should not be used by people with this type of thyroid cancer, or those with a condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), due to potential thyroid concerns identified in preclinical studies.
• Hypersensitivity to tirzepatide: Anyone who has had a serious allergic reaction to tirzepatide or any of the pen's other ingredients must not use it.

Groups where use requires careful prescriber assessment

• Pregnancy and breastfeeding: Mounjaro is not recommended during pregnancy or while breastfeeding. If you are pregnant, planning to conceive, or breastfeeding, speak to your prescriber or doctor promptly — this is a special-care topic requiring individual clinical guidance.
• People under 18: Mounjaro is not currently authorised for use in children or adolescents under 18 years of age.
• Severe gastrointestinal disease: Those with serious conditions affecting the stomach or bowel may not be suitable candidates, as the medicine affects gastric emptying.
• History of pancreatitis: A personal history of inflammation of the pancreas is a reason for caution and thorough prescriber review before use.
• Gallbladder disease: People with a history of gallbladder problems may face additional considerations.
• Diabetic retinopathy or rapidly worsening eye conditions: Those with certain eye complications related to diabetes should be monitored closely.
• Kidney or liver impairment: Severe impairment of kidney or liver function may affect suitability.

This list is not exhaustive. There may be other medicines a person is taking — including insulin or other diabetes medications — that affect suitability or require dose adjustments to other treatments. Your prescriber will have assessed your full medication list before prescribing.

For broader background on Mounjaro as a medicine, see our Mounjaro overview. You may also find it useful to read about detailed contraindications for Mounjaro, or to explore who manufactures Mounjaro and the company behind the medicine for general background.

GLP Trackr is not a clinical tool and cannot assess your suitability for any medicine — that judgement belongs entirely with your prescriber. What the app can do is help you keep a clear, organised record of what you experience while you are taking Mounjaro, so that any concerns are easy to raise at your next appointment.

The side-effect tracker lets you log symptoms — such as nausea, abdominal pain, or anything unusual — with dates and notes, building a timeline you can share directly with your healthcare professional. If something feels wrong, having a detailed log means your prescriber can make a more informed assessment than a verbal summary alone. The app also generates a doctor report summarising your tracked data, which you can bring to appointments.

If you are on Mounjaro and want to compare it with Wegovy (semaglutide), our Wegovy overview covers the key factual differences — though any decision about switching is always one to make with your prescriber, never independently.

Important: If you develop any new or worsening symptoms — particularly severe or persistent abdominal pain, signs of an allergic reaction, or any symptom that worries you — contact your healthcare professional promptly. Do not wait for a scheduled appointment. Any side effects should also be reported to your national pharmacovigilance scheme (such as the UK's Yellow Card scheme) as directed by your prescriber or the patient information leaflet that came with your medicine.

GLP Trackr is free to try for 7 days — available on the App Store and Google Play. Log your symptoms, track your journey, and walk into every prescriber appointment with the full picture at your fingertips.